Evidence map›Paper›PMID 34729307›Full record

ArticleActa pharmaceutica Sinica. B2021

Jianxiang Chen, Yiting Qiao, Guo Chen, Cunjie Chang, Heng Dong, Bo Tang, Xiawei Cheng, Xiufeng Liu, Zichun Hua

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
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  6. Review
  7. Optimization Strategies and Synergistic Applications of EngineeredInternational journal of nanomedicine · 2026
    Review
  8. AttenuatedFrontiers in immunology · 2026
    Review
  9. Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jianxiang ChenSchool of Life Sciences, Nanjing University, Nanjing 210023, China.
Yiting QiaoSchool of Life Sciences, Nanjing University, Nanjing 210023, China.
Guo ChenSchool of Life Sciences, Nanjing University, Nanjing 210023, China.
Cunjie ChangCollege of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou 311100, China.
Heng DongCollege of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou 311100, China.
Bo TangChangzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc., Changzhou 213164, China.
Xiawei ChengSchool of Life Sciences, Nanjing University, Nanjing 210023, China.
Xiufeng LiuSchool of Life Sciences, Nanjing University, Nanjing 210023, China.
Zichun HuaSchool of Life Sciences, Nanjing University, Nanjing 210023, China.
Nanjing University · CNHangzhou Normal University · CNChina Pharmaceutical University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models, but the detailed mechanism remains unsolved. In this report, the active involvement of the host immune response in this process was confirmed by comparing the tumor-suppressive effects of

Indexed as

AKT, Akt serine/threonine kinaseBacteria-mediated cancer therapyCancer immune therapyCFU, colony-forming unitsCTLA-4, cytotoxic T-lymphocyte-associated protein 4DN, dominant-negativeERBB2, Erb-B2 receptor tyrosine kinase 2ERKl, extracellular regulated protein kinase 1FlagellinFlagellumGAPDH, glyceraldehyde-3-phosphate dehydrogenaseGFP, green fluorescent proteinIFN-γ, interferon-γIL, interleukinsi.p., intraperitoneallyi.t., intratumorallyIκB, inhibitor of NF-κBJNK, c-Jun N-terminal kinaseLPS, lipopolysaccharideLRR, leucine-rich repeatMyD88, myeloid differentiation factor 88NF-κBNF-κB, nuclear factor kappa-BPBS, phosphate-buffered salinePCR, polymerase chain reactionPD-1, programmed cell death protein-1PD-L1, programmed cell death-ligand 1PEI, polyethylenimineSalmonellaTIR, Toll/Interleukin-1 receptorTLR5TLR, Toll-like receptorTME, tumor microenvironmentTRAF6, TNF receptor associated factor 6VNP20009

Identifiers

PMID34729307
PMCPMC8546927
OpenAlexW3160716708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.