Evidence map›Paper›PMID 34729218›Full record

ArticleCentral European journal of urology2021

Bioptic prostatic inflammation correlates with false positive rates of multiparametric magnetic resonance imaging in detecting clinically significant prostate cancer.

Ugo Giovanni Falagario, Marco Recchia, Giovanni Silecchia, Paola Milillo, Alessia Francavilla, Salvatore Mariano Bruno, Oscar Selvaggio, Gian Maria Busetto, Francesca Sanguedolce, Luca Macarini and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Central European journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ugo Giovanni FalagarioDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Marco RecchiaDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Giovanni SilecchiaDepartment of Urology, Bonomo Teaching Hospital, Andria (BAT), Italy.
Paola MililloDepartment of Radiology, University of Foggia, Foggia, Italy.
Alessia FrancavillaDepartment of Radiology, University of Foggia, Foggia, Italy.
Salvatore Mariano BrunoDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Oscar SelvaggioDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Gian Maria BusettoDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Francesca SanguedolceDepartment of Pathology, University of Foggia, Foggia, Italy.
Luca MacariniDepartment of Radiology, University of Foggia, Foggia, Italy.
Giuseppe CarrieriDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Luigi CormioDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
University of Foggia · ITIcahn School of Medicine at Mount Sinai · USOspedale L. Bonomo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this article was to determine the impact of bioptic prostatic inflammation (PI) on the false positive rate of multiparametric magnetic resonance imaging (mp-MRI) in detecting clinically significant prostate ancer (csPCa). MATERIAL AND

methodsOur prostate biopsy database was queried to identify patients who underwent mp-MRI before PB at our institution. A dedicated uropathologist prospectively assessed bioptic PI using the Irani scores. We evaluated the association between mp-MRI findings, bioptic Gleason grade (GG) and aggressiveness of PI, and PCa detection.

resultsIn total, 366 men were included. In patients with Prostate Imaging Reporting and Data System (PIRADS) 4-5 lesions, the csPCa (GG ≥2) rate was significantly higher in those with low-grade than in those with high-grade PI (36% vs 29.7%; p = 0.002), and in those with low-aggressive than in those with high-aggressive PI (37.7% vs 30.1%; p = 0.0003). The false positive rates of PIRADS 4-5 lesions for any PCa were 34.2% and 57.8% for low- and high-grade PI, respectively (p = 0.002); similarly, they were 29.5% and 59.4% for mildly and highly-aggressive PI (p = 0.0003). Potential study limitations include its retrospective analysis and single-center study and lack of assessment of the type of PI.

conclusionsBioptic PI directly correlates with false positive rates of mp-MRI in detecting csPCa. Clinicians should be aware that PI remains the most common pitfall of mp-MRI.

Indexed as

multiparametric magnetic resonance imagingprostate biopsyprostate cancerprostatic inflammation

Identifiers

PMID34729218
PMCPMC8552932
OpenAlexW3210839033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.