Evidence map›Paper›PMID 34729071›Full record

ReviewJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2021

Anticoagulation therapy in COVID-19 patients with chronic kidney disease.

Mohammad Ali Shafiee, Sayyideh Forough Hosseini, Mojgan Mortazavi, Anahita Emami, Mahtab Mojtahed Zadeh, Sanaz Moradi, Pouyan Shaker

Open access · goldAbstract readReview
In one paragraph

Review in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Risk factors for death by COVID-19, public hospital in Ciudad Juárez, México.Revista medica del Instituto Mexicano del Seguro Social · 2026
    Observational
  2. Observational
  3. Article
  4. COVID-19 and cardiovascular disease in patients with chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  5. Targeting ACE2 as a potential prophylactic strategy against COVID-19-induced exacerbation of chronic kidney disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mohammad Ali ShafieeDepartment of Medicine, Division of General Internal Medicine, Toronto General Hospital, Toronto, Canada.
Sayyideh Forough HosseiniDepartment of Medicine, Division of General Internal Medicine, Toronto General Hospital, Toronto, Canada.
Mojgan MortazaviIsfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Anahita EmamiDepartment of Medicine, Division of General Internal Medicine, Toronto General Hospital, Toronto, Canada.
Mahtab Mojtahed ZadehDepartment of Medicine, Division of General Internal Medicine, Toronto General Hospital, Toronto, Canada.
Sanaz MoradiDepartment of Medicine, Division of General Internal Medicine, Toronto General Hospital, Toronto, Canada.
Pouyan ShakerDepartment of Medicine, Division of General Internal Medicine, Toronto General Hospital, Toronto, Canada.
Toronto General Hospital · CAIsfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coagulopathy and derangements in the coagulation parameters are significant features of COVID-19 infection, which increases the risk of disseminated intravascular coagulation, thrombosis, and hemorrhage in these patients, resulting in increased morbidity and mortality. In times of COVID-19, special consideration should be given to patients with concurrent chronic kidney disease (CKD) and COVID-19 (CKD/COVID-19 patients) as renal dysfunction increases their risk of thrombosis and hemorrhage, and falsely affects some of the coagulation factors, which are currently utilized to assess thrombosis risk in patients with COVID-19. Hence, we believe extra attention should be given to determining the risk of thrombosis and bleeding and optimizing the timing and dosage of anticoagulant therapy in this unique population of patients. CKD/COVID-19 patients are considered a high-risk population for thrombotic events and hemorrhage. Furthermore, effects of renal function on paraclinical and clinical data should be considered during the evaluation and interpretation of thrombosis risk stratification. Individualized evaluation of clinical status and kidney function is necessary to determine the best approach and management for anticoagulant therapy, whereas there is a lack of studies about the population of CKD/COVID-19 patients who need anticoagulant therapy now.

Indexed as

Anticoagulation therapychronic kidney diseasecoagulation systemCOVID-19D-dimer

Identifiers

PMID34729071
PMCPMC8506255
OpenAlexW3196685125

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.