Evidence map›Paper›PMID 34729050›Full record

ArticleJournal of carcinogenesis2021

Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for Li-Fraumeni syndrome.

Jinxin Miao, Rong Li, Arnaud J Van Wettere, Haoran Guo, Alexandru-Flaviu Tabaran, M Gerald O'Sullivan, Timothy Carlson, Patricia M Scott, Kuisheng Chen, Dongling Gao and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of carcinogenesis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Jinxin MiaoDepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA.
Rong LiDepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA.
Arnaud J Van WettereDepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA.
Haoran GuoSino-British Research Centre for Molecular Oncology, National Centre for International Research in Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Henan, China.
Alexandru-Flaviu TabaranCollege of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA.
M Gerald O'SullivanCollege of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA.
Timothy CarlsonCollege of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA.
Patricia M ScottDepartment of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, USA.
Kuisheng ChenDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Dongling GaoDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Huixiang LiDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yaohe WangSino-British Research Centre for Molecular Oncology, National Centre for International Research in Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Henan, China.
Zhongde WangDepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA.
Robert T CormierDepartment of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, USA.
Utah State University · USUniversity of Minnesota · USUniversity of Minnesota, Duluth · USQueen Mary University of London · GB

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
NCI NIH HHS P30 CA077598
6 · The paper itself

Abstract

backgroundThe MATERIALS AND

methodsThe recent application of CRISPR/Cas9 genetic engineering technology has permitted the emergence of golden Syrian hamsters as genetic models for wide range of diseases, including cancer. Here, the first cancer phenotype of

resultsHamsters that are homozygous for

conclusionsOverall, hamsters may provide insights into how

Indexed as

cancerhamstersTP53

Identifiers

PMID34729050
PMCPMC8531574
OpenAlexW3202922211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.