ArticleCancer management and research2021
Optimal Lymph Node Yield for Survival Prediction in Rectal Cancer Patients After Neoadjuvant Therapy.
Article in Cancer management and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methylene blue can increase the number of lymph nodes harvested in colorectal cancer: a meta-analysis.International journal of colorectal disease · 2023Pooled it
- Understanding Textbook outcome failure after robotic colorectal cancer surgery: a multicenter domain-specific analysis.Journal of robotic surgery · 2026Observational
- Optimizing lymph node harvest in laparoscopic colorectal cancer: predictors and station-specific lymph node submission solutions.Annals of coloproctology · 2026Article
- Significance of nodal yield after rectal resection in the TNT era: does count matter?BMC cancer · 2026Article
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Authors and funding
9 authors.
Funding
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Abstract
purposeA lymph node (LN) yield ≥12 is required to for accurate determination of nodal status for colorectal cancer but cannot always be achieved after neoadjuvant therapy. This study aims to determine the difference in LN yield from rectal cancer patients treated with and without neoadjuvant therapy and the effects of specific LN yields on survival. PATIENTS AND
methodsThe study cohort included a total of 4344 rectal cancer patients treated between January 2007 and December 2015, 2260 (52.03%) of whom received neoadjuvant therapy. Data were retrieved from the Taiwan nationwide cancer registry database. The minimum acceptable LN yield below 12 was investigated using the maximum area under the ROC curve.
resultsThe median LN yield was 12 (8-17) for patients who received neoadjuvant therapy and 17 (13-24) for those who did not. The recommended LN yield ≥12 was achieved in 82.73% of patients without and 57.96% of those with neoadjuvant therapy (
conclusionNeoadjuvant therapy significantly reduces the LN yield in subsequent surgery. A lower yield (LN ≥ 10) may be adequate for nodal evaluation in rectal cancer patients after neoadjuvant therapy.
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