Evidence map›Paper›PMID 34728983›Full record

ArticleJournal of clinical and experimental hepatology

Predictors of in-hospital Outcomes in Patients With Cirrhosis and Coronavirus Disease-2019.

Anshuman Elhence, Manas Vaishnav, Sagnik Biswas, Abhinav Anand, Deepak Gunjan, Saurabh Kedia, Soumya J Mahapatra, Baibaswata Nayak, Sabreena Sheikh, Kapil D Soni and 3 more

Abstract read
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. COVID-19 and liver injury in individuals with obesity.World journal of gastroenterology · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anshuman ElhenceDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Manas VaishnavDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Sagnik BiswasDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Abhinav AnandDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Deepak GunjanDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Saurabh KediaDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Soumya J MahapatraDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Baibaswata NayakDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Sabreena SheikhDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Kapil D SoniDepartment of Anaesthesiology, Pain Medicine and Critical Care. All India Institute of Medical Sciences, New Delhi, India.
Anjan TrikhaDepartment of Anaesthesiology, Pain Medicine and Critical Care. All India Institute of Medical Sciences, New Delhi, India.
Amit GoelDepartment of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
ShalimarDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Coronavirus disease-2019 (COVID-19) cases continue to increase globally. Poor outcomes in patients with COVID-19 and cirrhosis have been reported; predictors of outcome are unclear. The existing data is from the early part of the pandemic when variants of concern (VOC) were not reported. Aims: We aimed to assess the outcomes and predictors in patients with cirrhosis and COVID-19. We also compared the differences in outcomes between the first wave of pandemic and the second wave. Methods: In this retrospective analysis of a prospectively maintained database, data on consecutive cirrhosis patients (n = 221) admitted to the COVID-19 care facility of a tertiary care center in India were evaluated for presentation, the severity of liver disease, the severity of COVID-19, and outcomes. Results: The clinical presentation included: 18 (8.1%) patients had compensated cirrhosis, 139 (62.9%) acute decompensation (AD), and 64 (29.0%) had an acute-on-chronic liver failure (ACLF). Patients with ACLF had more severe COVID-19 infection than those with compensated cirrhosis and AD (54.7% vs. 16.5% and 33.3%, Conclusion: Patients with COVID-19 and cirrhosis have high mortality (40%), particularly those with ACLF (72%). A higher leukocyte count, creatinine, alkaline phosphatase, Child class, and MELD score are predictors of mortality.

Indexed as

ACLF, acute-on-chronic liver failureAD, acute decompensationAIH, autoimmune hepatitisalcoholAlk P, alkaline phosphataseALT, alanine aminotransferaseAST, aspartate aminotransferaseCOVID-19, Coronavirus disease-2019CTP, Child-Turcotte-PughEHPVO, extrahepatic portal vein obstructionHBVHBV, hepatitis B virusHCVHCV, hepatitis C virusINR, international normalized ratioMELD, model for end-stage liver diseaseMODS, multiorgan dysfunction syndromeNAAT, Nucleic Acid Amplification TestNAFLDNAFLD, nonalcoholic fatty liver diseaseNCPF, noncirrhotic portal fibrosisportal hypertensionTLC, Total leukocyte countVOC, variants of concernVOI, variants of interest

Identifiers

PMID34728983
PMCPMC8553413

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.