ReviewPediatric research2022
Diagnosis of neonatal sepsis: the past, present and future.
Review in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
138 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Neonatal sepsis in Ethiopia: unveiling the persistent burden through systematic review and meta-analysis.BMC pediatrics · 2026Pooled it
- Using molecular methods to diagnose, classify, and treat neonatal sepsis: a scoping review.Frontiers in pediatrics · 2025Pooled it
- Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis.BMC infectious diseases · 2023Pooled it
- Efficacy of IVIG therapy for patients with sepsis: a systematic review and meta-analysis.Journal of translational medicine · 2023Pooled it
- Diagnostic and prognostic predictive values of triggering receptor expressed on myeloid cell-1 expression in neonatal sepsis: A meta-analysis and systematic review.Frontiers in pediatrics · 2022Pooled it
- [Docosahexaenoic acid benefits on growth and body composition of septic neonates. Randomized trial].Revista medica del Instituto Mexicano del Seguro Social · 2025Trial
- Adjusted versus Targeted Fortification in Extremely Low Birth Weight Preterm Infants: Fortin Study-A Randomized Clinical Trial.Nutrients · 2024Trial
- Comparative Diagnostic Performance of RDW-to-Albumin and CRP-to-Albumin Ratios in Neonatal Sepsis: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Beyond Conventional Biomarkers: Exploring Soluble Programmed Death Ligand-1 (sPD-L1) in Neonatal Sepsis.Indian journal of pediatrics · 2026Article
- Molecular Characterization and Clinical Outcomes ofChildren (Basel, Switzerland) · 2026Article
- Reducing unnecessary antibiotic exposure among neonates evaluated for suspected early-onset sepsis through an adapted risk-stratification and antimicrobial stewardship pathway in northwest Ethiopia: a prospective quality improvement study.BMJ paediatrics open · 2026Article
- Neonatal Bloodstream Infections: A Narrative Review on Diagnostic and Therapeutic Challenges and Prospects in Developing Countries.Health science reports · 2026Article
- Article
- Diagnostic utility of neutrophil CD64 for early detection of neonatal sepsis in southwestern Nigeria: a comparative case-control study.BMC pediatrics · 2026Article
- Multiple cross displacement amplification coupled with a lateral flow biosensor for ultra-rapid and highly sensitive detection ofMicrobiology spectrum · 2026Article
- Evaluation of sequential serum amyloid A measurements for the prediction of sepsis and survival in critically ill neonatal foals.Journal of veterinary internal medicine · 2026Article
- Aligning neonatal sepsis triage diagnostics with WHO target product profiles in low- and middle-income countries.BMJ global health · 2026Review
- Diagnostic challenges and Gram-negative pathogen dominance in early- and late-onset neonatal infection in Manila, Philippines.Nature communications · 2026Article
- Multi-omics insights into immunometabolic dysregulation in neonatal sepsis for precision medicine.Molecular biology reports · 2026Review
- Sepsis in neonates with necrotizing enterocolitis: outcomes and predictive model.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Sepsis remains a significant cause of neonatal mortality and morbidity, especially in low- and middle-income countries. Neonatal sepsis presents with nonspecific signs and symptoms that necessitate tests to confirm the diagnosis. Early and accurate diagnosis of infection will improve clinical outcomes and decrease the overuse of antibiotics. Current diagnostic methods rely on conventional culture methods, which is time-consuming, and may delay critical therapeutic decisions. Nonculture-based techniques including molecular methods and mass spectrometry may overcome some of the limitations seen with culture-based techniques. Biomarkers including hematological indices, cell adhesion molecules, interleukins, and acute-phase reactants have been used for the diagnosis of neonatal sepsis. In this review, we examine past and current microbiological techniques, hematological indices, and inflammatory biomarkers that may aid sepsis diagnosis. The search for an ideal biomarker that has adequate diagnostic accuracy early in sepsis is still ongoing. We discuss promising strategies for the future that are being developed and tested that may help us diagnose sepsis early and improve clinical outcomes. IMPACT: Reviews the clinical relevance of currently available diagnostic tests for sepsis. Summarizes the diagnostic accuracy of novel biomarkers for neonatal sepsis. Outlines future strategies including the use of omics technology, personalized medicine, and point of care tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.