Evidence map›Paper›PMID 34728796›Full record

ArticleCellular & molecular immunology2021

Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8

Xiaoxiao Jin, Yan Ding, Shihui Sun, Xinyi Wang, Zining Zhou, Xiaotao Liu, Miaomiao Li, Xian Chen, Anran Shen, Yandan Wu and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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  9. Impaired and restored CD8Frontiers in immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Xiaoxiao Jin *Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Yan Ding *Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Shihui Sun *State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.
Xinyi WangDepartment of Microbiology and Immunology, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Zining ZhouDepartment of Microbiology and Immunology, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Xiaotao LiuDepartment of Microbiology and Immunology, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Miaomiao LiBlood Component Preparation Section, Jiangsu Province Blood Center, Nanjing, 210042, Jiangsu, China.
Xian ChenBlood Component Preparation Section, Jiangsu Province Blood Center, Nanjing, 210042, Jiangsu, China.
Anran ShenInstitute of Nephrology, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Yandan WuDepartment of Microbiology and Immunology, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Bicheng LiuInstitute of Nephrology, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Jianqiong ZhangDepartment of Microbiology and Immunology, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Jian LiLife Science & Technology School of Southeast University, Nanjing, 210096, Jiangsu, China.
Yi YangJiangsu Province Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Haibo QiuJiangsu Province Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Chuanlai ShenDepartment of Microbiology and Immunology, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China. chuanlaishen@seu.edu.cn.
Yuxian HeInstitute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. yhe@ipb.pumc.edu.cn.
Guangyu ZhaoState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China. guangyu0525@163.com.
Southeast University · CNZhongda Hospital Southeast University · CNJiangsu Province Blood Center · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNInstitute of Microbiology · BYInstitute of Microbiology · CNSoutheast University · BD

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82041006
6 · The paper itself

Abstract

Since severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific T cells have been found to play essential roles in host immune protection and pathology in patients with coronavirus disease 2019 (COVID-19), this study focused on the functional validation of T cell epitopes and the development of vaccines that induce specific T cell responses. A total of 120 CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell LineCOVID-19 VaccinesDrug Evaluation, PreclinicalEpitopes, T-LymphocyteFemaleHLA-A2 AntigenHumansImmunogenicity, VaccineMiceMice, Inbred C57BLMice, TransgenicPeptide LibrarySARS-CoV-2Vaccine DevelopmentCOVID-19 VaccinesEpitopes, T-LymphocyteHLA-A2 AntigenPeptide LibraryHLA-ASARS-CoV-2T cell epitopeVaccination

Identifiers

PMID34728796
PMCPMC8561351
OpenAlexW3209923446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.