Evidence map›Paper›PMID 34728777›Full record

ArticleScientific reports2021

Evaluation of axial length to identify the effects of monocular 0.125% atropine treatment for pediatric anisometropia.

Po-Hsiang Kao, Lan-Hsin Chuang, Chi-Chun Lai, Shin-Yi Chen, Ken-Kuo Lin, Jiahn-Shing Lee, Chiun-Ho Hou, Chueh-Tan Chen, Yu-Kai Kuo, Chi-Chin Sun and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Combination therapy for myopia control using defocus incorporated multiple segments spectacles in children refractory to higher-dose atropine.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  2. The Changing Natural History of Anisometropia: A Scoping Review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
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  11. IMI 2023 Digest.Investigative ophthalmology & visual science · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Po-Hsiang KaoDepartment of Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
Lan-Hsin ChuangDepartment of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Chi-Chun LaiDepartment of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Shin-Yi ChenDepartment of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Ken-Kuo LinCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Jiahn-Shing LeeCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Chiun-Ho HouCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Chueh-Tan ChenInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yu-Kai KuoDepartment of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Chi-Chin SunDepartment of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Chun-Fu LiuDepartment of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan. legendlcf@gmail.com.
Chang Gung University · TWChang Gung Memorial Hospital · TWKeelung Chang Gung Memorial Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

Chang Gung Memorial Hospital, Keelung, Taiwan CMRPG 2I0131
6 · The paper itself

Abstract

The aim of the study is to determine the effects of monocular 0.125% atropine daily treatment on the longer axial length (AL) eyes in children with pediatric anisometropia. This was a retrospective cohort study. The charts of children with anisometropia (aged 6-15 years) who had a > 0.2-mm difference in AL between the two eyes were reviewed. Children who received monocular treatment of 0.125% atropine in the eye with longer AL were included for final analysis. The main outcome measure was the difference in AL between the two eyes after treatment. Regression analysis was used to model the changes in AL according to the time of treatment in both eyes. Finally, forty eyes in 20 patients (mean age 10.2 years) were included in the analyses. During the treatment period, AL was controlled in the treated eyes (p = 0.389) but elongated significantly in the untreated eyes (p < 0.001). The difference in AL between the treated and untreated eyes decreased from 0.57 to 0.22 mm (p < 0.001) after the 1-year treatment period. In the regression model, the best fit for the relationship between changes in AL and time during the treatment period in the treated eyes was the quadratic regression model with a concave function. In conclusion, these data suggest that 0.125% atropine daily is an effective treatment to reduce the interocular difference of AL in eyes with axial anisometropia. This pilot study provides useful information for future prospective and larger studies of atropine for the treatment of pediatric axial anisometropia.

Indexed as

AdolescentAnisometropiaAtropineAxial Length, EyeBronchodilator AgentsChildCorneal TopographyHumansMyopiaPilot ProjectsRefraction, OcularRetrospective StudiesAtropineBronchodilator Agents

Identifiers

PMID34728777
PMCPMC8563952
OpenAlexW3208265750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.