ArticleJournal of exposure science & environmental epidemiology2022
Identifying periods of heightened susceptibility to lead exposure in relation to behavioral problems.
Article in Journal of exposure science & environmental epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Lead exposure and antisocial behavior: A systematic review of human and animal evidence.Environment international · 2025Pooled it
- Exploring the link between toxic metal exposure and ADHD: a systematic review of pb and hg.Journal of neurodevelopmental disorders · 2024Pooled it
- Lead Ammunition Use and Post-Shooting Hygiene Practices Among U.S. Firearm Owners.American journal of preventive medicine · 2026Article
- Multifactorial nutritional and metabolic risk profiles for behavioral outcomes in Chinese children: a cross-sectional study at a Health Management Center using explainable machine learning and principal component analysis.Translational pediatrics · 2026Article
- Blood Lead Concentrations and Depressive and Anxiety Symptoms in Childhood.JAMA network open · 2026Article
- Cumulative childhood lead exposure estimation and school-age IQ in a prospective birth cohort.Environmental health : a global access science source · 2025Article
- Prenatal and childhood exposures to heavy metals and their associations with child cognition, motor skills, behaviour and mental health.Essays in biochemistry · 2025Review
- Effects of Blood Lead Levels <10 µg/dL in School-Age Children and Adolescents: A Scoping Review.Pediatrics · 2024Article
- Identification of high lead exposure locations in Ohio at the census tract scale using a generalizable geospatial hotspot approach.Journal of exposure science & environmental epidemiology · 2024Article
- Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder.World journal of psychiatry · 2024Article
- Examining the shared etiology of psychopathology with genome-wide association studies.Physiological reviews · 2023Review
- Exposure to metal mixtures and neuropsychological functioning in middle childhood.Neurotoxicology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundLead exposure is associated with behavioral problems in children, but the age(s) of greatest susceptibility to low-level lead exposure is unknown.
objectiveWe evaluated the association of repeated blood lead concentrations with parent-reported behaviors to identify periods of heightened susceptibility during infancy and childhood (HOME Study; Cincinnati, OH; 2003-2006; n = 244).
methodsWe quantified lead in whole blood samples (ages 1, 2, 3, 4, 5, and 8 years) and assessed behavior using the Behavioral Assessment System for Children-2 (BASC-2; ages 2, 3, 4, 5, and 8 years). We used multiple informant models and modified Poisson regression to estimate covariate-adjusted associations of ln-transformed blood lead concentrations with continuous BASC-2 T-scores and the relative risk of behavior scores classified as at-risk or clinically significant, respectively.
resultsWe observed trends indicating that higher blood lead concentrations at all ages were adversely associated with scores on behavioral scales. On the Externalizing Problems and Adaptive Skills scales, these associations were strongest for blood lead concentrations at age 8 years (β = 3.1-point; 95% CI = 0.7, 5.4 and β = -2.2-point; 95% CI = -4.9, 0.5, respectively) compared with other ages. Overall, higher blood lead concentrations were associated with elevated risk of behavior scores classified as at-risk or clinically significant on the Adaptive Skills, Behavioral Symptom Index, and Externalizing Problems scales. SIGNIFICANCE: Contemporary levels of lead exposure during the first 8 years of life were associated with ADHD-related behaviors, specifically aggression, hyperactivity, and conduct problems. IMPACT STATEMENT: Our results highlight the importance of primary lead prevention across childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.