ArticleScientific reports2021
Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 81 citations in OpenAlex.
- Multifunctional Conductive Polymer Nanocomposite for Intelligent Pesticide Sensing: Trends, Challenges, and Future Prospects.Molecules (Basel, Switzerland) · 2026Review
- Attenuation of imidacloprid deleterious effect on hepatic and neural tissues via acetylsalicylic acid: targeting HMGB1/caspase-3 axis and inflammatory pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Mosquitocidal Activity and Enzyme Inhibition of Citrus sinensis Essential Oil Against Anopheles gambiae: In Vivo and In Silico Insights.Neotropical entomology · 2026Article
- Electrochemical Detection of Organophosphates Using Dual-Modal Enzyme-Based Biosensors.Analytical chemistry · 2026Article
- Crystal Surface Reactivity of Esterase@Zeolitic Imidazolate Framework Biocomposites.Journal of the American Chemical Society · 2026Article
- Ligand and structure-based toxicological assessment of (thio)semicarbazones on cholinesterases.Journal of computer-aided molecular design · 2026Article
- Multimodal Fusion-Driven Pesticide Residue Detection: Principles, Applications, and Emerging Trends.Nanomaterials (Basel, Switzerland) · 2025Review
- Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging.Archives of toxicology · 2025Article
- Biomarkers of Pesticide Exposure in a Traditional Brazilian Amazon Community.International journal of environmental research and public health · 2024Article
- Molecular interaction mechanisms on (-)-epigallocatechin-3-gallate improving activities of inhibited acetylcholinesterase by selected organophosphorus pesticides in vitro & vivo.Scientific reports · 2024Article
- Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.Archives of toxicology · 2024Article
- New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics.Biomolecules · 2024Article
- Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin.International journal of molecular sciences · 2024Article
- Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases.Biomolecules · 2024Article
- Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase.Arhiv za higijenu rada i toksikologiju · 2024Article
- Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities.Exposure and health · 2024Article
- Structure-Dependent Mechanism of Organophosphate Release from Albumin and Butyrylcholinesterase Adducts When Exposed to Fluoride Ion: A Comprehensive In Silico Study.International journal of molecular sciences · 2023Article
- Review
- Selenium Heals the Chlorpyrifos-Induced Oxidative Damage and Antioxidant Enzyme Levels in the Rat Tissues.Biological trace element research · 2023Article
- Therapy of Organophosphate Poisoning via Intranasal Administration of 2-PAM-Loaded Chitosomes.Pharmaceutics · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Toxicity of organophosphorus compounds (OPs) remains a major public health concern due to their widespread use as pesticides and the existence of nerve agents. Their common mechanism of action involves inhibition of enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which are crucial for neurotransmission. Both chronic and acute poisoning by OPs can leave long-lasting health effects even when the patients are treated with standard medical therapy. Therefore, an increasing urgency exists to find more effective oxime reactivators for compounds which are resistant to reactivation, especially phosphoramidates. Here, we investigated in silico and in vitro interactions and kinetics of inhibition for human cholinesterases with four organophosphate pesticides-ethoprophos, fenamiphos, methamidophos and phosalone. Overall, ethoprophos and fenamiphos displayed higher potency as inhibitors for tested cholinesterases. Our results show that methamidophos-inhibited hAChE was more susceptible to reactivation than hAChE inhibited by fenamiphos by selected oximes. Molecular modelling enabled an evaluation of interactions important for specificity and selectivity of both inhibition and reactivation of cholinesterases. Two newly developed reactivators-bispyridinium triazole oxime 14A and zwitterionic oxime RS194B possess remarkable potential for further development of antidotes directed against pesticides and related phosphoramidate exposures, such as nerve agents tabun or Novichoks.
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