Evidence map›Paper›PMID 34728694›Full record

ArticleScientific reports2021

A unique amphiphilic triblock copolymer, nontoxic to human blood and potential supramolecular drug delivery system for dexamethasone.

Irrum Mushtaq, Zareen Akhter, Muhammad Farooq, Farukh Jabeen, Ashfaq Ur Rehman, Sadia Rehman, Sidra Ayub, Bushra Mirza, Muhammad Siddiq, Farasat Zaman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Irrum MushtaqDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Zareen AkhterDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Muhammad FarooqDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Farukh JabeenDepartment of Chemistry and Biochemistry, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON, P3E 2C6, Canada.
Ashfaq Ur RehmanDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.
Sadia RehmanInstitute of Biomedical and Genetic Engineering, Islamabad, Pakistan.
Sidra AyubDepartment of Biochemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Bushra MirzaDepartment of Biochemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Muhammad SiddiqDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Farasat ZamanDepartment of Women's and Children's Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Bioclinicum J9:30, SE-171 74, Solna, Sweden. farasat.zaman@ki.se.
Quaid-i-Azam University · PKInstitute of Biomedical and Genetic Engineering · PKKarolinska University Hospital · SELaurentian University · CAShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The drug delivery system (DDS) often causes toxicity, triggering undesired cellular injuries. Thus, developing supramolecules used as DDS with tunable self-assembly and nontoxic behavior is highly desired. To address this, we aimed to develop a tunable amphiphilic ABA-type triblock copolymer that is nontoxic to human blood cells but also capable of self-assembling, binding and releasing the clinically used drug dexamethasone. We synthesized an ABA-type amphiphilic triblock copolymer (P2L) by incorporating tetra(aniline) TANI as a hydrophobic and redox active segment along with monomethoxy end-capped polyethylene glycol (mPEG

Indexed as

Drug Delivery SystemsDrug LiberationAntineoplastic Agents, HormonalDexamethasoneDrug CarriersHemolysisHumansLung NeoplasmsMicellesPolyethylene GlycolsPolymersTumor Cells, CulturedAntineoplastic Agents, HormonalDexamethasoneDrug CarriersMicellesmonomethoxypolyethylene glycolPolyethylene GlycolsPolymers

Identifiers

PMID34728694
PMCPMC8563740
OpenAlexW3210345876

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.