Evidence map›Paper›PMID 34728684›Full record

Trial reportScientific reports2021

Multichannel anodal tDCS over the left dorsolateral prefrontal cortex in a paediatric population.

Maike Splittgerber, Christoph Borzikowsky, Ricardo Salvador, Oula Puonti, Kiriaki Papadimitriou, Christoph Merschformann, Maria Chiara Biagi, Tristan Stenner, Hannah Brauer, Carolin Breitling-Ziegler and 9 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Non-invasive brain stimulation and neuroenhancement.Clinical neurophysiology practice · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Maike SplittgerberInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany. splittgerber@med-psych.uni-kiel.de.
Christoph BorzikowskyInstitute of Medical Informatics and Statistics, University Hospital Schleswig Holstein, Kiel University, Kiel, Germany.
Ricardo SalvadorNeuroelectrics, Barcelona, Spain.
Oula PuontiDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Kiriaki PapadimitriouInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
Christoph MerschformannInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
Maria Chiara BiagiNeuroelectrics, Barcelona, Spain.
Tristan StennerInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
Hannah BrauerDepartment of Child and Adolescent Psychiatry, Center for Integrative Psychiatry Kiel, University Medical Center Schleswig-Holstein, Kiel, Germany.
Carolin Breitling-ZieglerDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany.
Alexander Prehn-KristensenDepartment of Child and Adolescent Psychiatry, Center for Integrative Psychiatry Kiel, University Medical Center Schleswig-Holstein, Kiel, Germany.
Kerstin KrauelDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany.
Giulio RuffiniNeuroelectrics, Barcelona, Spain.
Anya PedersenClinical Psychology and Psychotherapy, Department of Psychology, University of Kiel, Kiel, Germany.
Frauke NeesInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
Axel ThielscherDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Astrid DempfleInstitute of Medical Informatics and Statistics, University Hospital Schleswig Holstein, Kiel University, Kiel, Germany.
Michael SiniatchkinClinic for Child and Adolescent Psychiatry and Psychotherapy, Protestant Hospital Bethel, University of Bielefeld, Campus Bielefeld Bethel, Bielefeld, Germany.
Vera MoliadzeInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany. moliadze@med-psych.uni-kiel.de.
Kiel University · DECopenhagen University Hospital · DKUniversity Hospital Magdeburg · DEEvangelisches Krankenhaus Bielefeld · DEUniversity of Lübeck · DE

Funding

Horizon 2020 Framework Programme 731827
6 · The paper itself

Abstract

Methodological studies investigating transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (lDLPFC) in paediatric populations are limited. Therefore, we investigated in a paediatric population whether stimulation success of multichannel tDCS over the lDLPFC depends on concurrent task performance and individual head anatomy. In a randomised, sham-controlled, double-blind crossover study 22 healthy participants (10-17 years) received 2 mA multichannel anodal tDCS (atDCS) over the lDLPFC with and without a 2-back working memory (WM) task. After stimulation, the 2-back task and a Flanker task were performed. Resting state and task-related EEG were recorded. In 16 participants we calculated the individual electric field (E-field) distribution. Performance and neurophysiological activity in the 2-back task were not affected by atDCS. atDCS reduced reaction times in the Flanker task, independent of whether atDCS had been combined with the 2-back task. Flanker task related beta oscillation increased following stimulation without 2-back task performance. atDCS effects were not correlated with the E-field. We found no effect of multichannel atDCS over the lDLPFC on WM in children/adolescents but a transfer effect on interference control. While this effect on behaviour was independent of concurrent task performance, neurophysiological activity might be more sensitive to cognitive activation during stimulation. However, our results are limited by the small sample size, the lack of an active control group and variations in WM performance.

Indexed as

Task Performance and AnalysisAdolescentChildCognitionCross-Over StudiesDorsolateral Prefrontal CortexDouble-Blind MethodFemaleHumansMaleMemory, Short-TermNeuropsychological TestsTranscranial Direct Current Stimulation

Identifiers

PMID34728684
PMCPMC8563927
OpenAlexW3208633074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.