Evidence map›Paper›PMID 34728681›Full record

ArticleScientific reports2021

The effect of age and sex on the expression of GABA signaling components in the human hippocampus and entorhinal cortex.

Jayarjun Ethiraj, Thulani Hansika Palpagama, Clinton Turner, Bert van der Werf, Henry John Waldvogel, Richard Lewis Maxwell Faull, Andrea Kwakowsky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
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  9. Article
  10. Resolving native GABANature · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Impact of aging on the GABAbioRxiv : the preprint server for biology · 2024
    Article
  15. Review
  16. Review
  17. Article
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jayarjun EthirajCentre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, School of Medical Sciences, University of Auckland, Auckland, New Zealand.
Thulani Hansika PalpagamaCentre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, School of Medical Sciences, University of Auckland, Auckland, New Zealand.
Clinton TurnerCentre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, School of Medical Sciences, University of Auckland, Auckland, New Zealand.
Bert van der WerfDepartment of Epidemiology and Biostatistics, Faculty of Medical and Health Sciences, School of Population Health, University of Auckland, Auckland, New Zealand.
Henry John WaldvogelCentre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, School of Medical Sciences, University of Auckland, Auckland, New Zealand.
Richard Lewis Maxwell FaullCentre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, School of Medical Sciences, University of Auckland, Auckland, New Zealand.
Andrea KwakowskyCentre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, School of Medical Sciences, University of Auckland, Auckland, New Zealand. a.kwakowsky@auckland.ac.nz.
University of Auckland · NZ

Funding

Alzheimers New Zealand 3718869Aotearoa Foundation, Centre for Brain Research, University of Auckland 3705579Freemasons New Zealand 3719321Health Research Council of New Zealand 3627373Neurological Foundation of New Zealand 848010
6 · The paper itself

Abstract

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the nervous system. The GABA signaling system in the brain is comprised of GABA synthesizing enzymes, transporters, GABAA and GABAB receptors (GABA

Indexed as

AdultAgedAged, 80 and overAge FactorsBrainEntorhinal CortexFemalegamma-Aminobutyric AcidHippocampusHumansMaleMiddle AgedReceptors, GABA-ASex FactorsSignal Transductiongamma-Aminobutyric AcidReceptors, GABA-A

Identifiers

PMID34728681
PMCPMC8563768
OpenAlexW3210587519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.