ArticleNature communications2021
C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Extraction, Purification of C‑Glycosides from Arisaema decipiens for Studying its Anti-Inflammatory and Bioactivities.ACS omega · 2026Article
- Enzymatic 1,4-addition of 2-hydroxy-3-keto-glucal for β-selective aryl-Chemical communications (Cambridge, England) · 2026Article
- Antimicrobial and antibiofilm actions of iridoids: a comprehensive mechanistic review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- The phytochemistry and pharmacological activities ofFrontiers in pharmacology · 2026Review
- Characterization of the initial degradation mechanism involved inApplied and environmental microbiology · 2025Article
- Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism.Gut microbes · 2025Article
- A large-scale curated and filterable dataset for cryo-EM foundation model pre-training.Scientific data · 2025Article
- Advances in macromolecular crystallography at the Photon Factory: automation from crystallization to structural determination.Journal of synchrotron radiation · 2025Article
- UGT708S6 from Dendrobium catenatum, catalyzes the formation of flavonoid C-glycosides.BMC biotechnology · 2024Article
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- Flavonoids Biotransformation by Human Gut BacteriumJournal of microbiology and biotechnology · 2024Article
- Fragmentation Patterns of Phenolic C-Glycosides in Mass Spectrometry Analysis.Molecules (Basel, Switzerland) · 2024Article
- Genomics and physiology ofMicrobial genomics · 2024Article
- Contemporary strategies and approaches for characterizing composition and enhancing biofilm penetration targeting bacterial extracellular polymeric substances.Journal of pharmaceutical analysis · 2024Review
- Evolution and separation of actinobacterial pyranose andApplied and environmental microbiology · 2024Article
- Glycoside-metabolizing oxidoreductase D3dgpA from human gut bacterium.Frontiers in bioengineering and biotechnology · 2024Article
- Determination of aloesone in rat plasma by LC-MS/MS spectrometry and its application in a pharmacokinetic study.Bioanalysis · 2024Article
- Article
- Biodegradation of the methylenedioxyphenyl group in piperine and its derivatives: discovery of a novel methylenetransferase in an actinomycete.Applied and environmental microbiology · 2023Article
- Mechanistic insights into glycoside 3-oxidases involved in C-glycoside metabolism in soil microorganisms.Nature communications · 2023Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-Glycosides, in which a sugar moiety is linked via a carbon-carbon (C-C) bond to a non-sugar moiety (aglycone), are found in our food and medicine. The C-C bond is cleaved by intestinal microbes and the resulting aglycones exert various bioactivities. Although the enzymes responsible for the reactions have been identified, their catalytic mechanisms and the generality of the reactions in nature remain to be explored. Here, we present the identification and structural basis for the activation of xenobiotic C-glycosides by heterocomplex C-deglycosylation enzymes from intestinal and soil bacteria. They are found to be metal-dependent enzymes exhibiting broad substrate specificity toward C-glycosides. X-ray crystallographic and cryo-electron microscopic analyses, as well as structure-based mutagenesis, reveal the structural details of these enzymes and the detailed catalytic mechanisms of their remarkable C-C bond cleavage reactions. Furthermore, bioinformatic and biochemical analyses suggest that the C-deglycosylation enzymes are widely distributed in the gut, soil, and marine bacteria.
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