ArticleNature communications2021
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
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Who cites it
39 citing papers in PubMed, 50 citations in OpenAlex.
- A cohort study on the A8G6 neutralizing antibody intranasal spray for preventing SARS-CoV-2 infection in healthcare workers.Genes & diseases · 2026Article
- Application of Orthoflavivirus Pseudovirus Technology in Antiviral Research.International journal of molecular sciences · 2026Review
- Structure-guided design of a bivalent SARS-CoV-2 mRNA vaccine with NTD stabilizing mutations enhances broad immunity.Frontiers in immunology · 2025Article
- Immune imprinting: The persisting influence of the first antigenic encounter with rapidly evolving viruses.Human vaccines & immunotherapeutics · 2024Review
- An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models.Nature communications · 2024Article
- A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug.Cell death & disease · 2024Article
- Article
- Prophylactic efficacy of an intranasal spray with 2 synergetic antibodies neutralizing Omicron.JCI insight · 2024Article
- Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD.Protein & cell · 2024Article
- Coronavac inactivated vaccine triggers durable, cross-reactive Fc-mediated phagocytosis activities.Emerging microbes & infections · 2023Article
- Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry.Nature communications · 2023Article
- Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19.Signal transduction and targeted therapy · 2023Article
- A Delta-Omicron Bivalent Subunit Vaccine Elicited Antibody Responses in Mice against Both Ancestral and Variant Strains of SARS-CoV-2.Vaccines · 2023Article
- Emerging Landscape of Nanobodies and Their Neutralizing Applications against SARS-CoV-2 Virus.ACS pharmacology & translational science · 2023Review
- Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants.Communications biology · 2023Article
- Natural selection shapes the evolution of SARS-CoV-2 Omicron in Bangladesh.Frontiers in genetics · 2023Article
- Article
- Conformational Dynamics of the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein.Biomedicines · 2022Article
- Structure-based neutralizing mechanisms for SARS-CoV-2 antibodies.Emerging microbes & infections · 2022Review
- The Third dose of CoronVac vaccination induces broad and potent adaptive immune responses that recognize SARS-CoV-2 Delta and Omicron variants.Emerging microbes & infections · 2022Article
Corrections and comments
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Authors and funding
46 authors at 5 institutions in 1 country.
Tingting Li *Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.ORCID 0000-0002-8076-9471
Xiaojian Han *Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Chenjian Gu *Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Hangtian Guo *Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.ORCID 0000-0001-5213-9600
Huajun Zhang *State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.ORCID 0000-0001-8161-3949
Yingming Wang *Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.ORCID 0000-0003-2622-4216
Chao HuDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Kai WangKey Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400010, China.ORCID 0000-0002-0137-1247
Fengjiang LiuShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.ORCID 0000-0002-9400-308X
Feiyang LuoDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Yanan ZhangKey Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Jie HuKey Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400010, China.
Wang WangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Shenglong LiDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Yanan HaoDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Meiying ShenDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, 150000, China.
Jingjing HuangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Yingyi LongDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Shuyi SongDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Ruixin WuDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Song MuDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Qian ChenDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Fengxia GaoDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Jianwei WangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Shunhua LongDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Luo LiDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China.
Yang WuKey Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Yan GaoShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.ORCID 0000-0002-9665-8645
Wei XuKey Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Xia CaiKey Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Di QuKey Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Zherui ZhangKey Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Hongqing ZhangKey Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Na LiKey Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Qingzhu GaoKey Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400010, China.
Guiji ZhangKey Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400010, China.
Changlong HeKey Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400010, China.
Wei WangInstitute of life sciences, Chongqing Medical University, Chongqing, 400010, China.ORCID 0000-0002-2870-0733
Xiaoyun JiState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, China.
Ni TangKey Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400010, China.ORCID 0000-0001-5830-8786
Zhenghong YuanKey Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.ORCID 0000-0003-0268-4891
Youhua XieKey Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China. yhxie@fudan.edu.cn.ORCID 0000-0002-2416-7708
Haitao YangShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. yanght@shanghaitech.edu.cn.ORCID 0000-0002-1875-3268
Bo ZhangKey Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China. zhangbo@wh.iov.cn.ORCID 0000-0002-8895-3679
Ailong HuangKey Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, 400010, China. ahuang@cqmu.edu.cn.ORCID 0000-0003-0148-7423
Aishun JinDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400010, China. aishunjin@cqmu.edu.cn.ORCID 0000-0001-9746-4220
Chongqing Medical University · CNShanghai Medical College of Fudan University · CNChinese Academy of Sciences · CNShanghaiTech University · CNHarbin Medical University · CN
Funding
Chongqing Medical University (CQMU) X4457
Abstract
Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 receptor binding domain (RBD) specific monoclonal antibodies (mAbs), 58G6, 510A5 and 13G9, with high neutralizing potency blocking authentic SARS-CoV-2 virus display remarkable efficacy against authentic B.1.351 virus. Surprisingly, structural analysis has revealed that 58G6 and 13G9 both recognize the steric region S
Indexed as
AnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralBinding SitesCOVID-19EpitopesHumansMiceMice, TransgenicMutationSARS-CoV-2Spike Glycoprotein, CoronavirusViral LoadWeight LossAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
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