Evidence map›Paper›PMID 34728528›Full record

ArticleDiabetes care2022

The Impact of Racial and Ethnic Health Disparities in Diabetes Management on Clinical Outcomes: A Reinforcement Learning Analysis of Health Inequity Among Youth and Young Adults in the SEARCH for Diabetes in Youth Study.

Anna R Kahkoska, Teeranan Pokaprakarn, G Rumay Alexander, Tessa L Crume, Dana Dabelea, Jasmin Divers, Lawrence M Dolan, Elizabeth T Jensen, Jean M Lawrence, Santica Marcovina and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. The Experience of Discrimination Impacts Technology Readiness and Psychosocial States of Minoritized Families Living With Type 1 Diabetes: Findings From the BEAD-T1D Pilot Study.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Role of Leptin in Obesity, Cardiovascular Disease, and Type 2 Diabetes.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Anna R Kahkoska1Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-2701-101X
Teeranan Pokaprakarn2Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
G Rumay Alexander3School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Tessa L Crume4Department of Epidemiology, Colorado School of Public Health, Aurora, CO.ORCID 0000-0002-5397-4154
Dana Dabelea4Department of Epidemiology, Colorado School of Public Health, Aurora, CO.ORCID 0000-0001-9514-8929
Jasmin Divers6Division of Health Services Research, Department of Foundations of Medicine, NYU Long Island School of Medicine, Mineola, NY.
Lawrence M Dolan7Division of Endocrinology, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Elizabeth T Jensen8Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC.ORCID 0000-0003-2704-6634
Jean M Lawrence9Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Santica Marcovina10Department of Medicine, Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, WA.
Amy K Mottl11Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-4258-1726
Catherine Pihoker12Department of Pediatrics, University of Washington, Seattle, WA.ORCID 0000-0001-9074-7770
Sharon H Saydah13Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA.
Michael R Kosorok2Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Elizabeth J Mayer-Davis1Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC.
University of North Carolina at Chapel Hill · USColorado School of Public Health · USUniversity of Washington · USCenters for Disease Control and Prevention · USCincinnati Children's Hospital Medical Center · USKaiser Permanente · USWake Forest University · US

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort StudyUC4DK108173 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAGOSTINO, RALPH B. · 2015 to 2016
$14.8M
UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
SEARCH for Diabetes in Youth Coordinating CenterU01DP000250 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BELL, RONNY A · 2005 to 2009
$4.8M
SEARCH For Diabetes in Youth, Phase 3: Cohort Study-Carolina CenterU18DP002708 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2010 to 2014
$3.6M
SEARCH for Diabetes in Youth 2: Colorado CenterU01DP000247 · DP · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2005 to 2009
$3.6M
ACL HHS U18DP006131ACL HHS U18DP006133ACL HHS U18DP006134ACL HHS U18DP006136ACL HHS U18DP006138ACL HHS U18DP006139EPA EP-C-15-002HSRD VA HIR 10-001NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 TR001450NCATS NIH HHS UL1 TR002489NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01 DP000246NCCDPHP CDC HHS U01 DP000247NCCDPHP CDC HHS U01 DP000248NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U01 DP000254NCCDPHP CDC HHS U18 DP002708NCCDPHP CDC HHS U18 DP002709NCCDPHP CDC HHS U18 DP002710NCCDPHP CDC HHS U18 DP002714NCCDPHP CDC HHS U18 DP006131NCCDPHP CDC HHS U18 DP006133NCCDPHP CDC HHS U18 DP006134NCCDPHP CDC HHS U18 DP006136NCCDPHP CDC HHS U18 DP006138NCCDPHP CDC HHS U18 DP006139NIDDK NIH HHS F30 DK113728NIDDK NIH HHS P30 DK057516NIDDK NIH HHS R01 DK127208NIDDK NIH HHS UC4 DK108173
6 · The paper itself

Abstract

objectiveTo estimate difference in population-level glycemic control and the emergence of diabetes complications given a theoretical scenario in which non-White youth and young adults (YYA) with type 1 diabetes (T1D) receive and follow an equivalent distribution of diabetes treatment regimens as non-Hispanic White YYA. RESEARCH DESIGN AND

methodsLongitudinal data from YYA diagnosed 2002-2005 in the SEARCH for Diabetes in Youth Study were analyzed. Based on self-reported race/ethnicity, YYA were classified as non-White race or Hispanic ethnicity (non-White subgroup) versus non-Hispanic White race (White subgroup). In the White versus non-White subgroups, the propensity score models estimated treatment regimens, including patterns of insulin modality, self-monitored glucose frequency, and continuous glucose monitoring use. An analysis based on policy evaluation techniques in reinforcement learning estimated the effect of each treatment regimen on mean hemoglobin A1c (HbA1c) and the prevalence of diabetes complications for non-White YYA.

resultsThe study included 978 YYA. The sample was 47.5% female and 77.5% non-Hispanic White, with a mean age of 12.8 ± 2.4 years at diagnosis. The estimated population mean of longitudinal average HbA1c over visits was 9.2% and 8.2% for the non-White and White subgroup, respectively (difference of 0.9%). Within the non-White subgroup, mean HbA1c across visits was estimated to decrease by 0.33% (95% CI -0.45, -0.21) if these YYA received the distribution of diabetes treatment regimens of the White subgroup, explaining ∼35% of the estimated difference between the two subgroups. The non-White subgroup was also estimated to have a lower risk of developing diabetic retinopathy, diabetic kidney disease, and peripheral neuropathy with the White youth treatment regimen distribution (P < 0.05), although the low proportion of YYA who developed complications limited statistical power for risk estimations.

conclusionsMathematically modeling an equalized distribution of T1D self-management tools and technology accounted for part of but not all disparities in glycemic control between non-White and White YYA, underscoring the complexity of race and ethnicity-based health inequity.

Indexed as

Diabetes Mellitus, Type 1EthnicityAdolescentBlood GlucoseBlood Glucose Self-MonitoringChildFemaleGlycated HemoglobinHealth InequitiesHumansMaleYoung AdultBlood GlucoseGlycated Hemoglobin

Identifiers

PMID34728528
PMCPMC8753766
OpenAlexW3211293050

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.