Evidence map›Paper›PMID 34728283›Full record

ArticleJournal of affective disorders2022

Impulsivity and sleep and circadian rhythm disturbance predict next-day mood symptoms in a sample at high risk for or with recent-onset bipolar spectrum disorder: An ecological momentary assessment study.

Madison K Titone, Namni Goel, Tommy H Ng, Laura E MacMullen, Lauren B Alloy

Open access · greenAbstract read
In one paragraph

Article in Journal of affective disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Madison K TitoneDepartment of Psychology, Temple University, Philadelphia, PA, United States. Electronic address: madison.titone@temple.edu.
Namni GoelDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, United States.
Tommy H NgDepartment of Psychology, Temple University, Philadelphia, PA, United States.
Laura E MacMullenDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Lauren B AlloyDepartment of Psychology, Temple University, Philadelphia, PA, United States.
Temple University · USRush University Medical Center · USUniversity of Pennsylvania · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 1986 to 2026
$48.3M
Risk for Bipolar Disorder: Reward-related Brain Function & Social RhythmsR01MH077908 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2007 to 2017
$5.7M
Integrated Reward-Circadian Rhythm Model of First Onset of Bipolar Spectrum Disorders in Adolescence SupplementR01MH126911 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH, NUSSLOCK, ROBIN · 2021 to 2025
$3.8M
Impact of Daytime vs. Delayed Eating Schedule on Weight and Metabolic Markers Among Obese Persons: An Examination of Circadian MechanismsR01DK117488 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ALLISON, KELLY C, GOEL, NAMNI · 2017 to 2021
$3.8M
Social and Circadian Rhythms, Reward Sensitivity, and Risk for Bipolar DisorderR01MH102310 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2014 to 2017
$1.6M
NCATS NIH HHS UL1 TR001873NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK117488NIMH NIH HHS R01 MH077908NIMH NIH HHS R01 MH102310NIMH NIH HHS R01 MH126911
6 · The paper itself

Abstract

backgroundImpulsivity and sleep and circadian rhythm disturbance are core features of bipolar spectrum disorders (BSDs) that are antecedents to onset and persist even between mood episodes; their pervasive presence in BSD suggests that they may be particularly relevant to understanding BSD onset and course. Considerable research demonstrates bidirectional associations between impulsivity and sleep disturbance in healthy individuals; thus, it is important to examine how these features interact to impact BSD symptomatology.

methodsYoung adults (N = 107, 55% female, M age = 21.82 years) at high risk for developing BSD (based on high self-reported reward sensitivity) or with recent-onset BSD participated in ecological momentary assessment (EMA) to examine relationships between impulsivity, sleep and circadian rhythm alterations, and mood symptoms in everyday life. Impulsivity was measured via self-report/behavioral task, sleep was measured via actigraphy, circadian rhythms were measured via dim light melatonin onset (DLMO) time, and mood symptoms were measured three times daily via self-report.

resultsMulti-level modeling revealed that less total sleep time predicted increased next-day mood symptoms. Moreover, DLMO, total sleep time, and sleep onset latency moderated the relationship between impulsivity and EMA-assessed mood symptoms. Fewer minutes of sleep and later DLMO strengthened the positive relationship between impulsivity and mood symptoms. LIMITATIONS: Mood symptoms in our sample were mild; future studies should replicate findings in populations with more severe mood symptoms.

conclusionsThis multi-method assessment of dynamic relationships revealed novel associations between impulsivity, sleep and circadian rhythm disturbance, and symptoms within individuals at high-risk for or with recent-onset BSD.

Indexed as

Bipolar DisorderMelatoninAdultCircadian RhythmEcological Momentary AssessmentFemaleHumansImpulsive BehaviorMaleSleepYoung AdultMelatoninBipolar disorderCircadian rhythmDepressionImpulsive behaviorManiaSleep

Identifiers

PMID34728283
PMCPMC8643329
OpenAlexW3211138624

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.