Evidence map›Paper›PMID 34728234›Full record

ArticleThe Journal of pediatrics2022

Characteristics of Neonates with Cardiopulmonary Disease Who Experience Seizures: A Multicenter Study.

Shavonne L Massey, Hannah C Glass, Renée A Shellhaas, Sonia Bonifacio, Taeun Chang, Catherine Chu, Maria Roberta Cilio, Monica E Lemmon, Charles E McCulloch, Janet S Soul and 4 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 2 countries.

Shavonne L MasseyDivision of Neurology, Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA. Electronic address: masseysl@chop.edu.
Hannah C GlassDepartments of Neurology and UCSF Weill Institute for Neuroscience, University of California, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Renée A ShellhaasDepartment of Pediatrics, University of Michigan, Ann Arbor, MI.
Sonia BonifacioDepartment of Pediatrics, Stanford University, Stanford, CA.
Taeun ChangDepartment of Neurology, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC.
Catherine ChuDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Maria Roberta CilioDepartments of Pediatrics, Saint-Luc University Hospital, Catholic University of Louvain, Brussels, Belgium.
Monica E LemmonDepartment of Pediatrics and Population Health Sciences, Duke University School of Medicine, Durham, NC.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Janet S SoulDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Cameron ThomasDepartment of Pediatrics, Division of Neurology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.
Courtney J WusthoffDepartments of Neurology and Pediatrics, Stanford University, Stanford, CA.
Rui XiaoDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA.
Nicholas S AbendDivision of Neurology, Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA; Department of Anesthesia and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA.
Children's Hospital of Philadelphia · USStanford University · USUniversity of California, San Francisco · USBoston Children's Hospital · USCincinnati Children's Hospital Medical Center · USCliniques Universitaires Saint-Luc · BEDuke University · USGeorge Washington University · USHarvard University · USUniversity of Michigan · USUniversity of Pennsylvania · US

Funding

The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ERIC D MARSH, ROBERT Thomas SCHULTZ · 2021 to 2026
$9.2M
A Multicenter Study of EEG in Premature Infants with Neonatal EncephalopathyK02NS102598 · NINDS · STANFORD UNIVERSITY · PI WUSTHOFF, COURTNEY JANE · 2017 to 2019
$606k
NICHD NIH HHS P50 HD105354NINDS NIH HHS K02 NS102598
6 · The paper itself

Abstract

objectiveTo compare key seizure and outcome characteristics between neonates with and without cardiopulmonary disease. STUDY

designThe Neonatal Seizure Registry is a multicenter, prospectively acquired cohort of neonates with clinical or electroencephalographic (EEG)-confirmed seizures. Cardiopulmonary disease was defined as congenital heart disease, congenital diaphragmatic hernia, and exposure to extracorporeal membrane oxygenation. We assessed continuous EEG monitoring strategy, seizure characteristics, seizure management, and outcomes for neonates with and without cardiopulmonary disease.

resultsWe evaluated 83 neonates with cardiopulmonary disease and 271 neonates without cardiopulmonary disease. Neonates with cardiopulmonary disease were more likely to have EEG-only seizures (40% vs 21%, P < .001) and experience their first seizure later than those without cardiopulmonary disease (174 vs 21 hours of age, P < .001), but they had similar seizure exposure (many-recurrent electrographic seizures 39% vs 43%, P = .27). Phenobarbital was the primary initial antiseizure medication for both groups (90%), and both groups had similarly high rates of incomplete response to initial antiseizure medication administration (66% vs 68%, P = .75). Neonates with cardiopulmonary disease were discharged from the hospital later (hazard ratio 0.34, 95% CI 0.25-0.45, P < .001), although rates of in-hospital mortality were similar between the groups (hazard ratio 1.13, 95% CI 0.66-1.94, P = .64).

conclusionNeonates with and without cardiopulmonary disease had a similarly high seizure exposure, but neonates with cardiopulmonary disease were more likely to experience EEG-only seizures and had seizure onset later in the clinical course. Phenobarbital was the most common seizure treatment, but seizures were often refractory to initial antiseizure medication. These data support guidelines recommending continuous EEG in neonates with cardiopulmonary disease and indicate a need for optimized therapeutic strategies.

Indexed as

EpilepsySeizuresAnticonvulsantsElectroencephalographyHumansInfant, NewbornMonitoring, PhysiologicPhenobarbitalAnticonvulsantsPhenobarbitalbrain injurycongenital diaphragmatic herniacongenital heart diseaseECMOEEG monitoringneonatal neurocritical careneonatal seizures

Identifiers

PMID34728234
PMCPMC8882137
OpenAlexW3208927887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.