Evidence map›Paper›PMID 34727928›Full record

SynthesisHealth and quality of life outcomes2021

Instruments to assess quality of life in people with mental health problems: a systematic review and dimension analysis of generic, domain- and disease-specific instruments.

F C W van Krugten, K Feskens, J J V Busschbach, L Hakkaart-van Roijen, W B F Brouwer

Abstract readSystematic Review
In one paragraph

Synthesis in Health and quality of life outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Systematic review of the psychometric properties of quality-of-life outcome measures used with adult inpatient psychiatric populations.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. A systematic review of health state utility values and psychometric performance of generic preference-based instruments for children and adolescents with mental health problems.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Pooled it
  5. Pooled it
  6. Development of the Japanese version of the Manchester short assessment of quality of life (MANSA) among people with self-reported severe mental illness.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Psychometric properties comparison of EQ-5D-Y-3L and CHU9D in children and adolescents across different BMI classifications in Jiangsu, China.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  12. Toward developing more effective screening questionnaires for obstructive sleep apnoea: a conceptual model and testing.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  13. Article
  14. Schizophrenia.Nature reviews. Disease primers · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Methodological quality of 100 recent systematic reviews of health-related outcome measurement instruments: an overview of reviews.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Review
  20. Interventions for smoking cessation in inpatient psychiatry settings.The Cochrane database of systematic reviews · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

F C W van KrugtenErasmus School of Health Policy and Management, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands. vankrugten@eshpm.eur.nl.ORCID http://orcid.org/0000-0001-8592-3581
K FeskensErasmus School of Health Policy and Management, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands.
J J V BusschbachDepartment of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands.
L Hakkaart-van RoijenErasmus School of Health Policy and Management, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands.
W B F BrouwerErasmus School of Health Policy and Management, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe importance of economic evaluations of mental healthcare interventions is increasingly recognized. Despite the multitude of available quality of life instruments, concerns have been raised regarding the content validity of these instruments, and hence suitability for use in mental health. The aim of this paper, therefore, was to assess the content validity and the suitability of existing quality of life instruments for use in economic evaluations in mental health problems.

methodsIn order to identify available quality of life instruments used in people with mental health problems, a systematic review was performed using the Embase, Medline and PsycINFO databases (time period January 2012 to January 2018). Two reviewers independently assessed study eligibility and executed data extraction. The evaluation framework of Connell and colleagues was used to assess whether the identified quality of life instruments cover the dimensions valued highly by people with mental health problems. Two reviewers independently mapped the content of each identified instrument onto the evaluation framework and indicated the extent to which the instrument covered each of the dimensions of the evaluation framework.

resultsSearches of databases yielded a total of 5727 references. Following duplicate removal and double-independent screening, 949 studies were included in the qualitative synthesis. A total of 44 unique quality of life instruments were identified, of which 12 were adapted versions of original instruments. The best coverage of the dimensions of the evaluation framework of Connell and colleagues was by the WHOQOL-100, S-QoL, SQLS, EDQoL, QLI and the IMHQOL, but none fully covered all dimensions of the evaluation framework.

conclusionsThe results of this study highlight the multitude of available quality of life instruments used in people with mental health problems and indicate that none of the available quality of life instruments fully cover the dimensions previously found to be important in people with mental health problems. Future research should explore the possibilities of refining or expanding existing instruments as well as the development and testing of new quality of life instruments to ensure that all relevant quality of life dimensions for people with mental health problems are covered in evaluations.

Indexed as

Mental HealthQuality of LifeCost-Benefit AnalysisHumansCost-effectivenessMental healthPatient-reported outcome measuresQALYQuality of lifeSystematic review

Identifiers

PMID34727928
PMCPMC8561965

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.