Evidence map›Paper›PMID 34727758›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [

Yasushi Hattori, Chie Seki, Jun Maeda, Yuji Nagai, Kazunobu Aoyama, Ming-Rong Zhang, Takafumi Minamimoto, Tatsuki Koike, Makoto Higuchi

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Chemical Probes for Investigating the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
    Review
  3. Article
  4. Exploration of (R)-[European journal of nuclear medicine and molecular imaging · 2025
    Article
  5. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yasushi HattoriTakeda Pharmaceutical Company Limited, Kanagawa, Japan.
Chie SekiNational Institutes for Quantum Science and Technology, Chiba, Japan.
Jun MaedaNational Institutes for Quantum Science and Technology, Chiba, Japan.
Yuji NagaiNational Institutes for Quantum Science and Technology, Chiba, Japan.
Kazunobu AoyamaTakeda Pharmaceutical Company Limited, Kanagawa, Japan.
Ming-Rong ZhangNational Institutes for Quantum Science and Technology, Chiba, Japan.
Takafumi MinamimotoNational Institutes for Quantum Science and Technology, Chiba, Japan.ORCID 0000-0003-4305-0174
Tatsuki KoikeTakeda Pharmaceutical Company Limited, Kanagawa, Japan.
Makoto HiguchiNational Institutes for Quantum Science and Technology, Chiba, Japan.
National Institutes for Quantum Science and Technology · JPTakeda (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase that cleaves monoacylglycerols into fatty acids and is a potential target for the novel treatment of CNS disorders related to the endocannabinoid system and neuroinflammation. We have developed [

Indexed as

Monoacylglycerol LipasesPositron-Emission TomographyAnimalsBrainLigandsMacaca mulattaLigandsMonoacylglycerol Lipases[18F]T-401Monoacylglycerol lipase (MAGL)non-human primatesoccupancypositron emission tomography (PET)

Identifiers

PMID34727758
PMCPMC8943622
OpenAlexW3209375497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.