ArticleThe Journal of international medical research2021
Docking protein 1 and free fatty acids are associated with insulin resistance in patients with type 2 diabetes mellitus.
Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Investigation of Spexin Effects on Insulin-Dependent Pathway Genes in High-Glucose-Induced Insulin-Resistant C2C12 Myotubes.FASEB bioAdvances · 2026Article
- Inhibitory effects of the flavonoids extracted from Pollen Typhae on palmitic acid-induced NLRP3 inflammasome activation in macrophages involving AMPK-mediated lipid metabolism.BMC complementary medicine and therapies · 2025Article
- Effect and underlying mechanism of Huangjing Qianshi decoction in pre-diabetes mouse model.BMC complementary medicine and therapies · 2025Article
- Non-linear associations of a body shape index with diabetes among adults: A cross-sectional study.PloS one · 2025Article
- Experimental and Emerging Free Fatty Acid Receptor Agonists for the Treatment of Type 2 Diabetes.Medicina (Kaunas, Lithuania) · 2022Review
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
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Abstract
objectiveInsulin resistance (IR) is a key defect in type 2 diabetes mellitus (T2DM); therefore, effective means of ameliorating IR are sought.
methodsWe performed a retrospective cohort study of 154 patients with T2DM and 39 with pre-diabetes (pre-DM). The effects of IR and a high concentration of FFA on gene expression were determined using microarray analysis and quantitative reverse transcription polymerase chain reaction (RT-qPCR) in patients with T2DM or pre-DM.
resultsSerum FFA concentration and homeostasis model assessment of IR (HOMA-IR) were significantly higher in patients with T2DM but no obesity and in those with pre-DM than in controls. HOMA-IR was significantly associated with T2DM. RT-qPCR showed that the expression of FBJ murine osteosarcoma viral oncogene homolog (
conclusionsFFA and DOK1 are associated with IR in patients with T2DM but no obesity or pre-DM. The downregulation of DOK1 might inhibit lipid synthesis and induce lipolysis, inducing or worsening IR.
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