Evidence map›Paper›PMID 34727345›Full record

ArticleNeurology and therapy2022

Use of a Novel EEG-Based Objective Test, the Cognalyzer

Dan Bosnyak, Alison C McDonald, Israel Gasperin Haaz, Weikai Qi, David C Crowley, Najla Guthrie, Malkanthi Evans

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07680608 (Neurophysiological, Sleep-Related, and Mood Effects of a Cosmetic Shampoo and Conditioner Regimen in Adults With Scalp Discomfort and Sleep Difficulty), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07680608 completednot on this mapstarted 2025, after this paper: background citation

Neurophysiological, Sleep-Related, and Mood Effects of a Cosmetic Shampoo and Conditioner Regimen in Adults With Scalp Discomfort and Sleep Difficulty: A Pilot EEG-Based Observational Study

TypeobservationalSponsorZentrela Inc.Ran2025 to 2026Enrolled21ConditionsDandruffArmsCosmetic Shampoo and Conditioner Regimen
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dan BosnyakZentrela Inc. Suite B21, 175 Longwood Rd S, Hamilton, ON, L8P 0A1, Canada. dbosnyak@zentrela.com.ORCID http://orcid.org/0000-0002-8761-4050
Alison C McDonaldKGK Science Inc., 255 Queens Ave, London, ON, N6A 5R8, Canada.
Israel Gasperin HaazZentrela Inc. Suite B21, 175 Longwood Rd S, Hamilton, ON, L8P 0A1, Canada.
Weikai QiZentrela Inc. Suite B21, 175 Longwood Rd S, Hamilton, ON, L8P 0A1, Canada.
David C CrowleyKGK Science Inc., 255 Queens Ave, London, ON, N6A 5R8, Canada.
Najla GuthrieKGK Science Inc., 255 Queens Ave, London, ON, N6A 5R8, Canada.
Malkanthi EvansKGK Science Inc., 255 Queens Ave, London, ON, N6A 5R8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCurrent methods to detect recent delta-9-tetrahydrocannabinol (THC) use cannot objectively quantify its psychoactive effects (PE). The Cognalyzer

methodsSeventy-five participants were enrolled in the study. Prior to ad libitum cannabis inhalation, an EEG recording episode was completed. Immediately after inhalation, the Drug Effects Questionnaire (DEQ) was administered and another EEG recording performed. For 25 participants, the study ended. For 50 participants, assessments were repeated at 30-min intervals for 4 h. EEG files were blinded and analyzed using two versions of the Cognalyzer

resultsThere were significant PE increases from pre-cannabis for up to 3.5 h. Mean reports of feeling drug effects were > 0 at all post-inhalation time points (p ≤ 0.024). Furthermore, there were significant relationships between the Cognalyzer

conclusionThe findings show that the Cognalyzer

Indexed as

Cannabis effectsCognalyzer®Drug testEEGPsychoactiveTHC effect

Identifiers

PMID34727345
PMCPMC8857346

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.