ArticleThe international journal of cardiovascular imaging2022
Right ventricular afterload in repaired D-TGA is associated with inefficient flow patterns, rather than stenosis alone.
Article in The international journal of cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Systemic Right Ventricle: Is Equal Fitness Truly Equal?CJC pediatric and congenital heart disease · 2026Article
- Evaluation of Operated Dextro-Transposition of Great Arteries Patients in Follow-Up: Comparison of Transthoracic Echocardiography and Cardiac CT Angiography.Diagnostics (Basel, Switzerland) · 2025Article
- Characteristics of altered biventricular hemodynamics after arterial switch operation for patients with d-transposition of the great arteries with preserved ejection fraction: a four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) study.Quantitative imaging in medicine and surgery · 2024Article
- Shape and flow characterization of the pulmonary arteries after the LeCompte maneuver.JRSM cardiovascular diseaseArticle
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Authors and funding
7 authors.
Funding
Abstract
Treatment of D- transposition of great arteries (DTGA) involves the Arterial Switch Operation (ASO), which can create PA branch stenosis (PABS) and alter PA blood flow energetics. This altered PA flow may contribute to elevated right ventricular (RV) afterload more significantly than stenosis alone. Our aim was to correlate RV afterload and PA flow characteristics using 4D flow cardiac magnetic resonance (CMR) imaging of a mock circulatory system (MCS) incorporating 3D printed replicas. CMR imaging and clinical characteristics were analyzed from 22 ASO patients (age 11.9 ± 8.7 years, 68% male). Segmentation was performed to create 3D printed PA replicas that were mounted in an MRI-compatible MCS. Pressure drop across the PA replica was recorded and 4D flow CMR acquisitions were analyzed for blood flow inefficiency (energy loss, vorticity). In post-ASO patients, there is no difference in RV mass (p = 0.07), nor RV systolic pressure (p = 0.26) in the presence or absence of PABS. 4D flow analysis of MCS shows energy loss is correlated to RV mass (p = 0.01, r = 0.67) and MCS pressure differential (p = 0.02, r = 0.57). Receiver operating characteristic curve shows energy loss detects elevated RV mass above 30 g/m
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