SynthesisPediatric nephrology (Berlin, Germany)2022
Association between fluid overload and mortality in newborns: a systematic review and meta-analysis.
Synthesis in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Risk factors for acute kidney injury in very-low birth weight newborns: a systematic review with meta-analysis.European journal of pediatrics · 2024Pooled it
- Lung ultrasound-guided fluid resuscitation in neonatal septic shock: A randomized controlled trial.European journal of pediatrics · 2024Trial
- Weight changes and variability in the first week of life: associations with mortality in extremely preterm newborns.Pediatric nephrology (Berlin, Germany) · 2026Article
- Bridging evidence and practice: implementation science and bundled care strategies for fluid management in critically ill neonates.Frontiers in medicine · 2026Article
- Evidence-based risk stratification for neonatal acute kidney injury: a call to action.Pediatric nephrology (Berlin, Germany) · 2025Article
- Incidence of and risk factors for acute kidney injury in neonates with congenital diaphragmatic hernia.European journal of pediatrics · 2025Article
- Evaluation of anticoagulant methods in newborns undergoing continuous renal replacement therapy: what is the optimum method?European journal of pediatrics · 2025Article
- Fluid accumulation in critically ill children: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Assessing fluid responsiveness with ultrasound in the neonatal intensive care setting: the mini-fluid challenge.European journal of pediatrics · 2024Article
- Treatment approaches to horses with acute diarrhea admitted to referral institutions: A multicenter retrospective study.PloS one · 2024Article
- Real-life effects, complications, and outcomes in 39 critically ill neonates receiving continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2023Article
- Management of Acute Kidney Injury in Critically Ill Children.Indian journal of pediatrics · 2023Review
- Fluid balance in pediatric critically ill patients (with and without kidney dysfunction).Current opinion in critical care · 2022Review
- Challenges in Pediatric Fluid Management: Insights into Nursing Practices and Knowledge.Sage open pediatricsArticle
- A Standardized Approach to Reduce Fluid Overload in Critically Ill Children.Pediatric quality & safetyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluid overload (FO) is associated with higher rates of mortality and morbidity in pediatric and adult populations. The aim of this systematic review and meta-analysis was to investigate the association between FO and mortality in critically ill neonates. Systematic search of Ovid MEDLINE, EMBASE, Cochrane Library, trial registries, and gray literature from inception to January 2021. We included all studies that examined neonates admitted to neonatal intensive care units and described FO and outcomes of interest. We identified 17 observational studies with a total of 4772 critically ill neonates who met the inclusion criteria. FO was associated with higher mortality (OR, 4.95 [95% CI, 2.26-10.87]), and survivors had a lower percentage of FO compared with nonsurvivors (WMD, - 4.33 [95% CI, - 8.34 to - 0.32]). Neonates who did not develop acute kidney injury (AKI) had lower FO compared with AKI patients (WMD, - 2.29 [95% CI, - 4.47 to - 0.10]). Neonates who did not require mechanical ventilation on postnatal day 7 had lower fluid balance (WMD, - 1.54 [95% CI, - 2.21 to - 0.88]). FO is associated with higher mortality, AKI, and need for mechanical ventilation in critically ill neonates in the intensive care unit. Strict control of fluid balance to prevent FO is essential. A higher resolution version of the Graphical abstract is available as Supplementary information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.