ArticleCerebral cortex (New York, N.Y. : 1991)2022
Age Differences of the Hierarchical Cognitive Control and the Frontal Rostro-Caudal Functional Brain Activation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Different structural brain patterns and their association with executive function and general cognitive ability in cognitively normal elderly adults.Frontiers in aging neuroscience · 2026Article
- Neural correlates of span capacity during visual discrimination under varying cognitive demands.Scientific reports · 2025Article
- Aging disrupts the link between network centrality and functional properties of prefrontal neurons during memory-guided behavior.Communications biology · 2025Article
- Compensatory brain activity pattern is not present in older adults during the n-back task performance-Findings based on EEG frequency analysis.Frontiers in psychology · 2024Article
- Age differences in the functional organization of the prefrontal cortex: analyses of competing hypotheses.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
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Abstract
Age-related differences in the functional hierarchical organization of the frontal lobe remain unclear. We adopted task-related functional magnetic resonance imaging (fMRI) to investigate age differences in the functional hierarchical organization of the frontal lobe. Behavioral results report both reaction time and efficiency declined as the levels of abstraction increased in the selection of a set of stimulus-response mappings in older adults compared with young adults. fMRI findings suggest trends of the hierarchical organization along the rostro-caudal axis in both groups, and brain-behavior correlation further suggests neural dedifferentiation in older adults when performing at the highest level of control demands experiment. Behavioral performances and age difference overactivations at the highest level of control demands were both associated with working memory capacity, suggesting the working memory capacity is important for processing the highest task demands. Region-of-interest analysis revealed age differences in brain overactivation and common activation across experiments in the primary motor cortex, parietal lobule, and the fusiform gyrus may serve as shared mechanisms underlying tasks that are required for the selection of stimulus-response mapping sets. Overall, older adults reflect maladaptive overactivation in task-irrelevant regions that are detrimental to performance with the highest control demands.
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Registered trials
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