Evidence map›Paper›PMID 34727173›Full record

GuidelineBlood advances2022

American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on postdischarge thromboprophylaxis.

Adam Cuker, Eric K Tseng, Robby Nieuwlaat, Pantep Angchaisuksiri, Clifton Blair, Kathryn Dane, Jennifer Davila, Maria T DeSancho, David Diuguid, Daniel O Griffin and 43 more

Open access · goldAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Blood advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  9. Article
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  11. Article
  12. A systematic review on post-discharge venous thromboembolism prophylaxis in patients with COVID-19.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Review
  13. Review
  14. Thromboinflammation in long COVID-the elusive key to postinfection sequelae?Journal of thrombosis and haemostasis : JTH · 2023
    Review
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

53 authors at 20 institutions in 10 countries.

Adam CukerPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-3595-5697
Eric K TsengDivision of Hematology/Oncology; St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-2745-8057
Robby NieuwlaatMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Pantep AngchaisuksiriDivision of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Clifton BlairUnion, NJ.
Kathryn DaneDepartment of Pharmacy, The Johns Hopkins Hospital, Baltimore, MD.
Jennifer DavilaDivision of Pediatric Hematology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY.
Maria T DeSanchoOncology, and Cellular Therapies, Division of Hematology-Oncology, Department of Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY.
David DiuguidCoagulation Service, Section of Hematology.
Daniel O GriffinDivision of Infectious Diseases, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY.ORCID 0000-0001-5853-6906
Susan R KahnDepartment of Medicine, McGill University, Montreal, QC, Canada.ORCID 0000-0002-5667-8916
Frederikus A KlokDivision of Thrombosis and Hemostasis, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-9961-0754
Alfred Ian LeeSection of Hematology, Yale School of Medicine, New Haven, CT.ORCID 0000-0002-5968-3948
Ignacio NeumannDepartment of Internal Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Ashok PaiDivision of Hematology and Oncology, Kaiser Permanente, Oakland/Richmond, CA.
Marc RighiniDivision of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Kristen M SanfilippoDivision of Hematology, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-0433-7845
Deborah SiegalDepartment of Medicine and the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0003-3806-3245
Mike SkaraCottage Grove, MN.
Deirdra R TerrellDepartment of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK.ORCID 0000-0003-0794-5851
Kamshad TouriToronto, ON, Canada.
Elie A AklDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.ORCID 0000-0002-3444-8618
Reyad Nayif Al JabiriDepartment of Medicine, University of Jordan, Amman, Jordan.
Yazan Nayif Al JabiriLincoln Medical Center, Bronx, NY.
Angela M BarbaraDepartment of Health Research Methods, Evidence, and Impact, Health Sciences Centre, McMaster University, Hamilton, ON, Canada.
Antonio BognanniMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-0128-903X
Imad Bou AklDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.
Mary BoulosDepartment of Health Research Methods, Evidence, and Impact, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-5046-598X
Romina Brignardello-PetersenDepartment of Health Research Methods, Evidence, and Impact, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-6010-9900
Rana CharideClinical Research Institute, American University of Beirut, Beirut, Lebanon.ORCID 0000-0001-5512-0091
Matthew ChanDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Luis E Colunga-LozanoDepartment of Clinical Medicine, Health Science Center, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.ORCID 0000-0001-7737-4914
Karin DearnessLibrary Services, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.ORCID 0000-0002-6854-0156
Andrea J DarziMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-2498-1697
Heba HusseinDepartment of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Cairo, Egypt.ORCID 0000-0001-6042-361X
Samer G KaramMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-5167-4246
Philipp KolbMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Razan MansourOffice of Scientific Affairs and Research, King Hussein Cancer Center, Amman, Jordan.ORCID 0000-0002-7719-9068
Gian Paolo MorganoMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-7577-7963
Rami Z MorsiDepartment of Neurology, University of Chicago, Chicago, IL.ORCID 0000-0003-2131-3711
Giovanna Muti-SchünemannMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Menatalla K NadimDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID 0000-0003-1506-3613
Atefeh NooriMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-0141-3718
Binu A PhilipMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Thomas PiggottMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-1643-5386
Yuan QiuMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-9572-9106
Yetiani Roldan BenitezMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Finn SchünemannMedizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.
Adrienne StevensMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-6257-4806
Karla SoloMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-6134-9140
Wojtek WierciochMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-6576-1650
Reem A MustafaMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-2091-0875
Holger J SchünemannMichael G. DeGroote Cochrane Canada and McGRADE Centre, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-3211-8479
Cochrane · CAAmerican University of Beirut · LBMcMaster University · CAImpact · CAUniversity of Freiburg · DEAin Shams University · EGAlbert Einstein College of Medicine · USCairo University · EGCottage Grove Community Medical Center · USHealth Sciences Centre · CAJohns Hopkins Hospital · USKaiser Permanente Oakland Medical Center · USKing Hussein Cancer Center · JOLeiden University Medical Center · NLLincoln Medical Center · USMahidol University · THMcGill University · CANewYork–Presbyterian Hospital · USPontificia Universidad Católica de Chile · CLProHealth Care · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Life after Recovery in Adult Thrombotic Thrombocytopenic Purpura (TTP): Let's Hear It from the SurvivorsK01HL135466 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI TERRELL, DEIRDRA R · 2017 to 2021
$687k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K01 HL135466
6 · The paper itself

Abstract

backgroundCOVID-19-related acute illness is associated with an increased risk of venous thromboembolism (VTE).

objectiveThese evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in decisions about the use of anticoagulation for thromboprophylaxis in patients with COVID-19 who do not have confirmed or suspected VTE.

methodsASH formed a multidisciplinary guideline panel, including 3 patient representatives, and applied strategies to minimize potential bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline development process, including performing systematic evidence reviews (up to March 2021). The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The panel used the grading of recommendations assessment, development, and evaluation (GRADE) approach to assess evidence and make recommendations, which were subject to public comment.

resultsThe panel agreed on 1 additional recommendation. The panel issued a conditional recommendation against the use of outpatient anticoagulant prophylaxis in patients with COVID-19 who are discharged from the hospital and who do not have suspected or confirmed VTE or another indication for anticoagulation.

conclusionsThis recommendation was based on very low certainty in the evidence, underscoring the need for high-quality randomized controlled trials assessing the role of postdischarge thromboprophylaxis. Other key research priorities include better evidence on assessing risk of thrombosis and bleeding outcomes in patients with COVID-19 after hospital discharge.

Indexed as

COVID-19HematologyVenous ThromboembolismAftercareAnticoagulantsEvidence-Based MedicineHumansPatient DischargeSARS-CoV-2United StatesAnticoagulants

Identifiers

PMID34727173
PMCPMC8566097
OpenAlexW3211260362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.