Evidence map›Paper›PMID 34727127›Full record

ArticlePloS one2021

Dietary acrylamide and physical performance tests: A cross-sectional analysis.

Nicola Veronese, Ligia J Dominguez, Saverio Ragusa, Luisa Solimando, Lee Smith, Francesco Bolzetta, Stefania Maggi, Mario Barbagallo

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Nicola VeroneseGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.ORCID 0000-0002-9328-289X
Ligia J DominguezGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
Saverio RagusaGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
Luisa SolimandoGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
Lee SmithThe Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom.
Francesco BolzettaAzienda Unità Locale Socio Sanitaria 3 "Serenissima", Department of Internal Medicine, Geriatrics Section, Venice, Italy.
Stefania MaggiAging Branch, Neuroscience Institute, National Research Council, Padua, Italy.
Mario BarbagalloGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
University of Palermo · ITAnglia Ruskin University · GBAzienda Sanitaria Locale CN2 · ITNeuroscience Institute · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDietary acrylamide is found in certain foods, such as deep frying, baking and roasting, and is associated with higher inflammatory and oxidative stress parameters. The association between dietary acrylamide and physical performance has not yet been explored. The aim of the study was to investigate the relationship between dietary acrylamide intake and physical performance tests in a large cohort of North American individuals affected by knee osteoarthritis or at high risk for this condition.

methodsDietary acrylamide intake was obtained through a food frequency questionnaire and reported in quartiles and as an increase in deciles. Physical performance was explored using the 20-meter usual pace test, the 400-meter walking distance, and the chair stands time. The association between dietary acrylamide and physical performance tests was explored using linear regression analysis, adjusted for potential confounders.

results4,436 participants (2,578 women, mean age: 61.3) were enrolled. People in the highest quartile of dietary acrylamide reported significantly longer 20-meter walking (15.53±3.32 vs. 15.15±2.91 s), 400-meter walking (312±54 vs. 305±58 s) and chair stands (11.36±4.08 vs. 10.67±3.50 s) times than their counterparts in Q1. In adjusted linear regression analyses, each increase in one decile in dietary acrylamide was associated with a longer time in walking for 20 meters (beta = 0.032; 95%CI: 0.016-0.048; p = 0.04), 400 meters (beta = 0.048; 95%CI: 0.033-0.063; p = 0.002) and chair stands (beta = 0.016; 95%CI: 0.005-0.037; p = 0.04) times.

conclusionHigher dietary acrylamide intake was significantly associated with poor physical performance, also after accounting for potential confounders, suggesting a role for this food contaminant as a possible risk factor for sarcopenia.

Indexed as

AcrylamideDietAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedOsteoarthritis, KneePhysical Functional PerformanceWalkingAcrylamide

Identifiers

PMID34727127
PMCPMC8562801
OpenAlexW3209184187

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.