Evidence map›Paper›PMID 34727115›Full record

SynthesisPloS one2021

The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic review.

Natasha Marcella Vaselli, Daniel Hungerford, Ben Shenton, Arwa Khashkhusha, Nigel A Cunliffe, Neil French

Abstract readSystematic Review
In one paragraph

Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Observational
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  11. Serological surveillance of healthcare workers to evaluate natural infection- and vaccine-derived immunity to SARS-CoV-2 during an outbreak in Dili, Timor-Leste.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
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  14. Review
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  17. Assessment of SARS-CoV-2 Infection among Healthcare Workers of a German COVID-19 Treatment Center.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natasha Marcella VaselliInstitute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0003-0220-9249
Daniel HungerfordInstitute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0002-9770-0163
Ben ShentonInstitute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Arwa KhashkhushaSchool of Medicine, Faculty of Life Sciences, University of Liverpool, Liverpool, United Kingdom.
Nigel A CunliffeInstitute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Neil FrenchInstitute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA year following the onset of the COVID-19 pandemic, new infections and deaths continue to increase in Europe. Serological studies, through providing evidence of past infection, can aid understanding of the population dynamics of SARS-CoV-2 infection.

objectivesThis systematic review of SARS-CoV-2 seroprevalence studies in Europe was undertaken to inform public health strategies including vaccination, that aim to accelerate population immunity.

methodsWe searched the databases Web of Science, MEDLINE, EMBASE, SCOPUS, Cochrane Database of Systematic Reviews and grey literature sources for studies reporting seroprevalence of SARS-CoV-2 antibodies in Europe published between 01/12/2019-30/09/20. We provide a narrative synthesis of included studies. Studies were categorized into subgroups including healthcare workers (HCWs), community, outbreaks, pregnancy and children/school. Due to heterogeneity in other subgroups, we only performed a random effects meta-analysis of the seroprevalence amongst HCWs stratified by their country.

results115 studies were included spanning 17 European countries, that estimated the seroprevalence of SARS-CoV-2 from samples obtained between November 2019 -August 2020. A total of 54/115 studies included HCWs with a reported seroprevalence among HCWs ranging from 0.7% to 45.3%, which did not differ significantly by country. In community studies significant heterogeneity was reported in the seroprevalence between different age groups and the majority of studies reported there was no significant difference by gender.

conclusionThis review demonstrates a wide heterogeneity in reported seroprevalence of SARS-CoV-2 antibodies between populations. Continued evaluation of seroprevalence is required to understand the impact of public health measures and inform interventions including vaccination programmes.

Indexed as

COVID-19EuropeHumansPandemicsPublic HealthSeroepidemiologic Studies

Identifiers

PMID34727115
PMCPMC8562786

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.