ArticleIEEE transactions on bio-medical engineering2022
A New Oral Model to Assess Postprandial Lactate Production Rate.
Article in IEEE transactions on bio-medical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity.Obesity (Silver Spring, Md.) · 2025Article
- Hyperglycemia Suppresses Lactate Clearance During Exercise in Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2024Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivePediatric obesity predisposes children and adolescents to early onset insulin resistance and dysglycemia. In the last 20 years this has led to a rise in the prevalence of prediabetes, diabetes and fatty liver in youngsters, due to the high degree of insulin resistance experienced by these patients and the consequent high availability of glucose. As glucose accesses the liver, it is partly metabolized through glycolysis, whose main product is pyruvate that is then converted into Acetyl CoA and lactate. Therefore, lactate production rate (LPR) represents the best proxy for the assessment of glycolysis. Since to date there are not methods to estimate postprandial LPR, here we proposed a novel oral glucose-lactate model to estimate LPR during an oral glucose tolerance test and tested it in 24 youth with and without obesity.
methodsThe model is based on the oral glucose minimal model and assumes that LPR is a fraction (fr) of glucose disposal rate, proportional to glucose concentration and controlled by insulin action.
resultsThe model well fitted the glucose and lactate data, and provided both precise parameter estimates (e.g., fr = 22.5 [12.6-54.1]%, median [IQR]), CV = 18 [13-25]%) and LPR time course.
conclusionsThe proposed model is a valid tool to assess LPR, and thus glycolysis, during OGTT in nondiabetic subjects. SIGNIFICANCE: The proposed methodology will allow to assess postprandial LPR in simple and cost-effective way.
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