ArticleeLife2021
Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Modulation of Hamstrings Neural Drive During Isometric Contractions of the Hip Extensors and Knee Flexors.Scandinavian journal of medicine & science in sports · 2026Article
- Autogenic spinal excitatory circuit ensures skilled hand movements in primates.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Diverse Transcriptional Alterations in V2a Propriospinal Neurons Following Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A cholinergic spinal pathway for the adaptive control of breathing.Cell reports · 2025Article
- A cholinergic spinal pathway for the adaptive control of breathing.bioRxiv : the preprint server for biology · 2025Article
- Increased muscle coactivation is linked with fast feedback control when reaching in unpredictable visual environments.iScience · 2024Article
- Dissecting muscle synergies in the task space.eLife · 2024Article
- Multi-site lumbar transcutaneous spinal cord stimulation: When less is more.Neuroscience letters · 2024Article
- Medial and lateral vestibulospinal projections to the cervical spinal cord of the squirrel monkey.Frontiers in neurology · 2024Article
- Two motor neuron synergies, invariant across ankle joint angles, activate the triceps surae during plantarflexion.The Journal of physiology · 2023Article
- Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction.Current opinion in neurobiology · 2023Review
- Spinal Interneurons: Diversity and Connectivity in Motor Control.Annual review of neuroscience · 2023Review
- Pathophysiology of Dyt1-Science translational medicine · 2023Article
- Common synaptic input, synergies and size principle: Control of spinal motor neurons for movement generation.The Journal of physiology · 2023Review
- Dystonia-like behaviors and impaired sensory-motor integration following neurotoxic lesion of the pedunculopontine tegmental nucleus in mice.Frontiers in neurology · 2023Article
- Neuromuscular control: from a biomechanist's perspective.Frontiers in sports and active living · 2023Review
- Intermediate gray matter interneurons in the lumbar spinal cord play a critical and necessary role in coordinated locomotion.PloS one · 2023Article
- Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled.eLife · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Motoneurons (MNs) control muscle contractions, and their recruitment by premotor circuits is tuned to produce accurate motor behaviours. To understand how these circuits coordinate movement across and between joints, it is necessary to understand whether spinal neurons pre-synaptic to motor pools have divergent projections to more than one MN population. Here, we used modified rabies virus tracing in mice to investigate premotor interneurons projecting to synergist flexor or extensor MNs, as well as those projecting to antagonist pairs of muscles controlling the ankle joint. We show that similar proportions of premotor neurons diverge to synergist and antagonist motor pools. Divergent premotor neurons were seen throughout the spinal cord, with decreasing numbers but increasing proportion with distance from the hindlimb enlargement. In the cervical cord, divergent long descending propriospinal neurons were found in contralateral lamina VIII, had large somata, were neither glycinergic, nor cholinergic, and projected to both lumbar and cervical MNs. We conclude that distributed spinal premotor neurons coordinate activity across multiple motor pools and that there are spinal neurons mediating co-contraction of antagonist muscles.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.