ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021
Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Theory for sequence selection via phase separation and oligomerization.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- High-Yield Prebiotic Polymerization of 2',3'-Cyclic Nucleotides under Wet-Dry Cycling.ACS central science · 2025Article
- Phosphoric acid salts of amino acids as a source of oligopeptides on the early Earth.Communications chemistry · 2024Article
- Microfluidics-Based Drying-Wetting Cycles to Investigate Phase Transitions of Small Molecules Solutions.Life (Basel, Switzerland) · 2024Article
- Sequence self-selection by cyclic phase separation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context.iScience · 2023Article
- Review
- Prebiotic Foam Environments to Oligomerize and Accumulate RNA.Chembiochem : a European journal of chemical biology · 2022Article
- Sequencing the origins of life.BBA advances · 2022Review
- Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Questions and Answers Related to the Prebiotic Production of Oligonucleotide Sequences from 3',5' Cyclic Nucleotide Precursors.Life (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The assembly of ancient informational polymers from nucleotide precursors is the central challenge of life's origin on our planet. Among the possible solutions, dry polymerization of 3',5'-cyclic guanosine monophosphate (3',5'-cGMP) has been proposed as a candidate to create oligonucleotides of 15-20 units in length. However, the reported sensitivity of the reaction to the presence of cations raised questions of whether this chemistry could be relevant in a geological context. The experiments in this study show that the presence of cations is not restrictive as long as the reaction is conducted in an acidic environment, in contrast to previous reports that suggested optimal conditions at pH 9.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.