Evidence map›Paper›PMID 34726674›Full record

ArticlePhysical chemistry chemical physics : PCCP2021

Constant pH molecular dynamics of porcine circovirus 2 capsid protein reveals a mechanism for capsid assembly.

Elvira Tarasova, Noriaki Okimoto, Shanshan Feng, Dmitry Nerukh, Reza Khayat, Makoto Taiji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physical chemistry chemical physics : PCCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elvira TarasovaLaboratory for Computational Molecular Design, RIKEN Center for Biosystems Dynamics Research (BDR), 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan.ORCID http://orcid.org/0000-0001-5949-8235
Noriaki OkimotoLaboratory for Computational Molecular Design, RIKEN Center for Biosystems Dynamics Research (BDR), 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan.ORCID http://orcid.org/0000-0002-2956-1317
Shanshan FengDepartment of Chemistry and Biochemistry, The City College of New York, New York, New York, USA. rkhayat@ccny.cuny.edu.
Dmitry NerukhDepartment of Mathematics, Aston University, Birmingham, UK.ORCID http://orcid.org/0000-0001-9005-9919
Reza KhayatDepartment of Chemistry and Biochemistry, The City College of New York, New York, New York, USA. rkhayat@ccny.cuny.edu.ORCID http://orcid.org/0000-0001-6601-2184
Makoto TaijiLaboratory for Computational Molecular Design, RIKEN Center for Biosystems Dynamics Research (BDR), 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan.ORCID http://orcid.org/0000-0002-5317-0500

Funding

TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Cellular/Molecular Basis of Development: Research CenterG12MD007603 · NIMHD · CITY COLLEGE OF NEW YORK · PI PEZZANO, MARK · 2012 to 2017
$11.5M
Mechanism of cellular recognition and entry by a circovirusSC1AI114843 · NIAID · CITY COLLEGE OF NEW YORK · PI KHAYAT, REZA · 2014 to 2017
$1.4M
NIAID NIH HHS SC1 AI114843NIGMS NIH HHS P41 GM103310NIMHD NIH HHS G12 MD007603
6 · The paper itself

Abstract

Spatiotemporal regulation of viral capsid assembly ensures the selection of the viral genome for encapsidation. The porcine circovirus 2 is the smallest autonomously replicating pathogenic virus, yet how PCV2 capsid assembly is regulated to occur within the nucleus remains unknown. We report that pure PCV2 capsid proteins, in the absence of nucleic acids, require acidic conditions to assemble into empty capsids

Indexed as

Molecular Dynamics SimulationAnimalsCapsid ProteinsCircovirusHydrogen-Ion ConcentrationSwineThermodynamicsCapsid Proteins

Identifiers

PMID34726674
PMCPMC8705882

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.