Evidence map›Paper›PMID 34726583›Full record

ArticlePharmaceutical biology2021

Polyphenol containing

Kalahe Hewage Iresha Nadeeka Madushani Herath, Jinhee Cho, Hyo Jin Kim, Duong Thi Thuy Dinh, Hyun-Soo Kim, Ginnae Ahn, You-Jin Jeon, Youngheun Jee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kalahe Hewage Iresha Nadeeka Madushani HerathDepartment of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, Republic of Korea.ORCID 0000-0002-8607-2659
Jinhee ChoDepartment of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, Republic of Korea.ORCID 0000-0002-4402-8174
Hyo Jin KimDepartment of Food Bioengineering, Jeju National University, Jeju, Republic of Korea.ORCID 0000-0003-4342-4711
Duong Thi Thuy DinhInterdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju, Republic of Korea.ORCID 0000-0001-9664-1264
Hyun-Soo KimDepartment of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, Jeju, Republic of Korea.
Ginnae AhnDepartment of Food Technology and Nutrition, Chonnam National University, Yeosu, Republic of Korea.ORCID 0000-0002-1666-6048
You-Jin JeonDepartment of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, Jeju, Republic of Korea.ORCID 0000-0003-3299-7266
Youngheun JeeDepartment of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, Republic of Korea.ORCID 0000-0002-6295-0314
Jeju National University · KRChonnam National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

context

objectiveThis study clarifies the effect of polyphenol-containing MATERIALS AND

methodsAll mice (BALB/c mice,

resultsSHE (0-1000 µg/mL) was not cytotoxic to splenocytes and demonstrated IC

conclusionsSHE exhibits Th2 immune suppression under OVA stimulation via GATA3- and NLRP3-dependent IL-4, IL-5, and IL-13 suppression. Therefore, SHE could be therapeutically useful for alleviating the symptoms of allergen-mediated immune diseases.

Indexed as

AnimalsCytokinesDose-Response Relationship, DrugGATA3 Transcription FactorMiceMice, Inbred BALB CNLR Family, Pyrin Domain-Containing 3 ProteinOvalbuminPlant ExtractsPolyphenolsSargassumSpleenSTAT5 Transcription FactorTh2 CellsCytokinesGata3 protein, mouseGATA3 Transcription FactorNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseOvalbuminPlant ExtractsPolyphenolsStat5a protein, mouseSTAT5 Transcription FactorCD3+ CD4+ T cellIL-13Polyphenol

Identifiers

PMID34726583
PMCPMC8567878
OpenAlexW3210613443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.