Evidence map›Paper›PMID 34726496›Full record

ArticlemSystems2021

Identification and Development of Therapeutics for COVID-19.

Halie M Rando, Nils Wellhausen, Soumita Ghosh, Alexandra J Lee, Anna Ada Dattoli, Fengling Hu, James Brian Byrd, Diane N Rafizadeh, Ronan Lordan, Yanjun Qi and 14 more

Abstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. COVID-19 Therapeutics: Improvise-Adapt-Learn.Journal of clinical medicine · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Halie M RandoDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-7688-1770
Nils WellhausenDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8955-7582
Soumita GhoshInstitute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-2783-2750
Alexandra J LeeDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0208-3730
Anna Ada DattoliDepartment of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1462-831X
Fengling HuDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1081-5038
James Brian ByrdUniversity of Michigan School of Medicine, Ann Arbor, Michigan, USA.ORCID 0000-0002-0509-3520
Diane N RafizadehPerelman School of Medicine, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-2838-067X
Ronan LordanInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-9668-3368
Yanjun QiDepartment of Computer Science, University of Virginiagrid.27755.32, Charlottesville, Virginia, USA.ORCID 0000-0002-5796-7453
Yuchen SunDepartment of Computer Science, University of Virginiagrid.27755.32, Charlottesville, Virginia, USA.
Christian BruefferDepartment of Clinical Sciences, Lund University, Lund, Sweden.ORCID 0000-0002-3826-0989
Jeffrey M FieldDepartment of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-7161-7284
Marouen Ben GuebilaDepartment of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0001-5934-966X
Nafisa M JadavjiBiomedical Science, Midwestern Universitygrid.260024.2, Glendale, Arizona, USA.ORCID 0000-0002-3557-7307
Ashwin N SkellyPerelman School of Medicine, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1565-3376
Bharath RamsundarThe DeepChem Project.ORCID 0000-0001-8450-4262
Jinhui WangPerelman School of Medicine, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-5796-8130
Rishi Raj GoelInstitute for Immunology, University of Pennsylvaniagrid.25879.31 Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1715-5191
YoSon ParkDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvaniagrid.25879.31, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0465-4744
COVID-19 Review Consortium Vikas Bansal, John P. Barton, Simina M. Boca, Joel D. Boerckel, Christian Brueffer, James Brian Byrd, Stephen Capone, Shikta Das, Anna Ada Dattoli, John J. Dziak, Jeffrey M. Field, Soumita Ghosh, Anthony Gitter, Rishi Raj Goel, Casey S. Greene, Marouen Ben Guebila, Daniel S. Himmelstein, Fengling Hu, Nafisa M. Jadavji, Jeremy P. Kamil, Sergey Knyazev, Likhitha Kolla, Alexandra J. Lee, Ronan Lordan, Tiago Lubiana, Temitayo Lukan, Adam L. MacLean, David Mai, Serghei Mangul, David Manheim, Lucy D’Agostino McGowan, Amruta Naik, YoSon Park, Dimitri Perrin, Yanjun Qi, Diane N. Rafizadeh, Bharath Ramsundar, Halie M. Rando, Sandipan Ray, Michael P. Robson, Vincent Rubinetti, Elizabeth Sell, Lamonica Shinholster, Ashwin N. Skelly, Yuchen Sun, Yusha Sun, Gregory L. Szeto, Ryan Velazquez, Jinhui Wang, Nils Wellhausen
Simina M BocaInnovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.ORCID 0000-0002-1400-3398
Anthony GitterDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-5324-9833
Casey S GreeneDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0001-8713-9213

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007170 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BRASS, LAWRENCE F · 1985 to 2022
$54.0M
Network-based algorithms for target identification and drug repositioning from genetic associationsR01HG010067 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI GREENE, CASEY S · 2018 to 2022
$3.2M
A Novel Biomarker of Mineralocorticoid Receptor ActivationK23HL128909 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BYRD, JAMES BRIAN · 2016 to 2020
$972k
NHGRI NIH HHS R01 HG010067NHLBI NIH HHS K23 HL128909NIGMS NIH HHS T32 GM007170
6 · The paper itself

Abstract

After emerging in China in late 2019, the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a significant threat globally. Only a few coronaviruses are known to infect humans, and only two cause infections similar in severity to SARS-CoV-2:

Indexed as

COVID-19reviewtherapeutics

Identifiers

PMID34726496
PMCPMC8562484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.