ArticlePsychological trauma : theory, research, practice and policy2022
Estradiol, stress reactivity, and daily affective experiences in trauma-exposed women.
Article in Psychological trauma : theory, research, practice and policy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Hormonal mechanisms of women's risk in the face of traumatic stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Trial
- Associations Between Different Subtypes of Adverse Childhood Experiences with Reproductive Mood Disorders-a Scoping Review.Current psychiatry reports · 2026Article
- The lateral septum orchestrates state-dependent modulation of associative threat memory dynamics across the ovarian hormone cycle.bioRxiv : the preprint server for biology · 2026Article
- Scoping Review of Experience Sampling Methodology Investigations of Posttraumatic Stress Disorder Symptoms.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2026Article
- Gender specific associations between potentially traumatic life events and mental health.European journal of psychotraumatology · 2025Article
- Estradiol levels are differentially associated with pulse wave velocity in trauma-exposed premenopausal women with and without PTSD.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Long-lasting effects of post-traumatic stress disorder in Yazidi women living in Northern Iraqi camps.Journal of Taibah University Medical Sciences · 2024Article
- The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications.Frontiers in neuroendocrinology · 2024Review
- Trauma and female reproductive health across the lifecourse: motivating a research agenda for the future of women's health.Human reproduction (Oxford, England) · 2023Review
- Duration of exposure to epidural anesthesia at delivery, DNA methylation in umbilical cord blood and their association with offspring asthma in Non-Hispanic Black women.Environmental epigenetics · 2023Article
- Menstrual Cycle in Trauma-Related Disorders: A Mini-Review.Frontiers in global women's health · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveWomen experience higher risk for PTSD following trauma compared with men. Fluctuations in ovarian hormones might contribute to this greater vulnerability, given that estradiol is associated with affect and stress reactivity. Our objective was to test the relations between menstrual cycle-related changes in estradiol, affect, stress reactivity, and trauma-related symptoms.
methodWe assessed trauma-related symptoms in ethnically diverse naturally cycling women with a history of trauma during a clinical interview. Participants also completed a 10-day ecological momentary assessment (EMA) that included lower- and higher-estradiol phases. We tested associations between estradiol and PTSD symptoms and stress reactivity to a trauma reminder using Spearman correlation and Wilcoxon rank-sum tests. We tested the effect of menstrual cycle day on daily affect using multilevel modeling.
resultsEstradiol was negatively associated with symptom severity (
conclusionsConsistent with prior evidence of more aversive affective experiences in low-estradiol states, lower estradiol was associated with higher trauma-related symptoms. In addition, trauma-exposed women showed a discordant pattern of stress reactivity to a trauma reminder, higher daily symptoms, and greater affective lability in a low-estradiol phase. Given that our sample consisted of high-functioning trauma-exposed women, these results should be replicated in women with PTSD. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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Registered trials
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