Evidence map›Paper›PMID 34726356›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Suction-Cup-Inspired Adhesive Micromotors for Drug Delivery.

Lijun Cai, Cheng Zhao, Hanxu Chen, Lu Fan, Yuanjin Zhao, Xiaoyun Qian, Renjie Chai

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. A Lifetime of Catalytic Micro-/Nanomotors.Nanomaterials (Basel, Switzerland) · 2024
    Review
  9. Review
  10. Review
  11. Light-controlled soft bio-microrobot.Light, science & applications · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Self-Solidifying Active Droplets Showing Memory-Induced Chirality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lijun CaiDepartment of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline, Nanjing, 210008, China.ORCID 0000-0001-5464-3325
Cheng ZhaoDepartment of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline, Nanjing, 210008, China.
Hanxu ChenState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Lu FanState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Yuanjin ZhaoState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Xiaoyun QianDepartment of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline, Nanjing, 210008, China.
Renjie ChaiDepartment of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline, Nanjing, 210008, China.ORCID 0000-0002-3885-543X
Nanjing Drum Tower Hospital · CNState Key Laboratory of Digital Medical EngineeringNantong University · CN

Funding

National Key Research and Development Program of China 2020YFA0908200National Natural Science Foundation of China 52073060National Natural Science Foundation of China 81970882National Natural Science Foundation of China 81970885National Natural Science Foundation of China 82030029Natural Science Foundation from Jiangsu Province BE2019711Shenzhen Fundamental Research Program JCYJ20190813152616459Shenzhen Fundamental Research Program JCYJ20190814093401920Strategic Priority Research Program of the Chinese Academy of Science XDA16010303
6 · The paper itself

Abstract

Micromotors have opened novel avenues for drug delivery due to their capacity for self-propelling. Attempts in this field trend towards ameliorating their functions to promote their clinical applications. In this paper, an ingenious suction-cup-inspired micromotor is presented with adhesive properties for drug delivery in the stomach. The micromotors are fabricated by using hydrogel replicating the structure of suction-cup-like microparticles, which derive from self-assembly of colloidal crystals under rapid solvent extraction, followed by loading magnesium (Mg) in the bottom spherical surface. The Mg-loaded micromotors can realize spontaneous movement due to the continual generation of hydrogen bubbles in gastric juice. The combination of unique suction-cup-like structure with excellent motion performance makes the micromotor an ideal carrier for drug delivery as they can efficiently adhere to the tissue. Moreover, benefiting from the porous structure, the hydrogel micromotors exhibit a high volume-surface ratio, which enables efficient drug loading. It is demonstrated that the suction-cup-inspired micromotors can adhere efficiently to the ulcer-region in the stomach and release drugs due to their distinctive architecture and spontaneous motion, exhibiting desirable curative effect of gastric ulcer. Thus, the suction-cup-inspired micromotors with adhesive properties are expected to advance the development of micromotor in clinical applications.

Indexed as

AdhesivesDrug LiberationHumansHydrogelsMagnesiumNanoparticle Drug Delivery SystemPorosityStomachSuctionAdhesivesHydrogelsMagnesiumNanoparticle Drug Delivery Systemadhesionbio-inspireddrug deliveryhydrogelmicromotorsmicroparticles

Identifiers

PMID34726356
PMCPMC8728833
OpenAlexW3210759616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.