Evidence map›Paper›PMID 34726258›Full record

ArticleBritish journal of haematology2022

Red blood cell transfusion-induced non-transferrin-bound iron promotes Pseudomonas aeruginosa biofilms in human sera and mortality in catheterized mice.

Francesca La Carpia, Andrea Slate, Sheila Bandyopadhyay, Boguslaw S Wojczyk, Elizabeth A Godbey, Kevin P Francis, Kevin Prestia, Eldad A Hod

Open access · bronzeAbstract read
In one paragraph

Article in British journal of haematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Red Blood Cell Omics and Machine Learning in Transfusion Medicine: Singularity Is Near.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Francesca La CarpiaDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-1120-9307
Andrea SlateCenter for Comparative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Sheila BandyopadhyayDivision of Life Science, Department of Biological Science, School of Arts and Science, Rutgers University, Newark, NJ, USA.
Boguslaw S WojczykDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-3387-7223
Elizabeth A GodbeyDepartment of Pathology, Virginia Commonwealth University Health, Richmond, VA, USA.
Kevin P FrancisPerkinElmer, Hopkinton, MA, USA.
Kevin PrestiaDivision of Comparative Medicine, NYU Langone Health, New York, NY, USA.
Eldad A HodDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-2367-9509
Columbia University Irving Medical Center · USMassachusetts General Hospital · USNYU Langone Health · USPerkinElmer (United States) · USRutgers, The State University of New Jersey · USVirginia Commonwealth University · US

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
The safety of red blood cell transfusionsR01HL121275 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOD, ELDAD ARIE · 2014 to 2017
$1.6M
NCATS NIH HHS UL1 TR000040NHLBI NIH HHS R01 HL121275
6 · The paper itself

Abstract

Transfusion of storage-damaged red blood cells (RBCs) increases non-transferrin-bound iron (NTBI) levels in humans. This can potentially enhance virulence of microorganisms. In this study, Pseudomonas aeruginosa replication and biofilm production in vitro correlated with NTBI levels of transfused subjects (R

Indexed as

AnimalsBiofilmsErythrocytesErythrocyte TransfusionHealthy VolunteersHumansIronMaleMicePseudomonas aeruginosaSurvival AnalysisIronbiofilmblood transfusioninfectionironnon-transferrin bound iron

Identifiers

PMID34726258
PMCPMC8831455
OpenAlexW3209435133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.