ArticleThe Journal of clinical endocrinology and metabolism2022
Transient vs Permanent Congenital Hypothyroidism in Ontario, Canada: Predictive Factors and Scoring System.
Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Transient neonatal hypothyroidism due to maternal seaweed soup ingestion: a report of 3 cases.JCEM case reports · 2026Article
- Levothyroxine use and discontinuation in presumed congenital hypothyroidism: a 10-year nationwide cohort study.Pediatric research · 2026Article
- Permanent or Transient Congenital Hypothyroidism: A Diagnostic Dilemma.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Term birth and levothyroxine dosage are significant factors associated with permanent congenital hypothyroidism: experience from a medical center in Taiwan.BMC pediatrics · 2025Article
- Differentiating transient and permanent congenital hypothyroidism: predictive clues from Istanbul, Türkiye.Journal of pediatric endocrinology & metabolism : JPEM · 2025Article
- 50 YEARS OF NEWBORN SCREENING FOR CONGENITAL HYPOTHYROIDISM: EVOLUTION OF INSIGHTS IN ETIOLOGY, DIAGNOSIS AND MANAGEMENT: Transient or permanent congenital hypothyroidism: from milestones to current and future perspectives.European thyroid journal · 2025Review
- Predictive factors of permanent versus transient congenital hypothyroidism: a pragmatic cohort study.Annals of pediatric endocrinology & metabolism · 2025Article
- A practical gestational age-based algorithm for timely detection of hypothyroidism in premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Predictive Factors of Transient Congenital Hypothyroidism among Filipino Children: A Retrospective Study.Acta medica Philippina · 2025Article
- The natural course of newborns with transient congenital hypothyroidism.Endocrine connections · 2024Article
- High frequency of transient congenital hypothyroidism among infants referred for suspected congenital hypothyroidism from the Turkish National screening program: thyroxine dose may guide the prediction of transients.Journal of endocrinological investigation · 2024Observational
- Current Status of Newborn Bloodspot Screening Worldwide 2024: A Comprehensive Review of Recent Activities (2020-2023).International journal of neonatal screening · 2024Review
- De novo missense variants in exon 9 of SEPHS1 cause a neurodevelopmental condition with developmental delay, poor growth, hypotonia, and dysmorphic features.American journal of human genetics · 2024Article
- Diagnostic options, physiopathology, risk factors and genetic causes of permanent congenital hypothyroidism: A narrative review.Caspian journal of internal medicine · 2024Review
- Predictive factors for the diagnosis of permanent congenital hypothyroidism and its temporal changes in Sergipe, Brazil - A real-life retrospective study.Archives of endocrinology and metabolism · 2023Article
- MECHANISMS IN ENDOCRINOLOGY: The pathophysiology of transient congenital hypothyroidism.European journal of endocrinology · 2022Review
- Neonatal screening for congenital hypothyroidism: 28-year experience in the state of Minas Gerais, Brazil.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe apparent increased incidence of congenital hypothyroidism (CH) is partly due to increased detection of transient disease.
objectiveThis work aims to identify predictors of transient CH (T-CH) and establish a predictive tool for its earlier differentiation from permanent CH (P-CH).
methodsA retrospective cohort study was conducted of patients diagnosed with CH from 2006 to 2015 through Newborn Screening Ontario (NSO).
resultsOf 469 cases, 360 (76.8%) were diagnosed with P-CH vs 109 (23.2%) with T-CH. Doses of levothyroxine predicting T-CH were less than 3.9 μg/kg at age 6 months, less than 3.0 μg/kg at ages 1 and 2 years, and less than 2.5 μg/kg at age 3 years. Descriptive statistics and multivariable logistic modeling demonstrated several diverging key measures between patients with T-CH vs P-CH, with optimal stratification at age 1 year. Thyroid imaging was the strongest predictor (P < .001). Excluding imaging, significant predictors in the first year of life included thyroxine dose/kg (P < .001-.002), increase in thyrotropin (TSH) above the reference interval during treatment (P = .002), screening TSH (P = .03), and a history of maternal thyroid disease (P = .02). Based on the 1-year model without imaging, a risk score was developed to identify children with T-CH who may benefit from an earlier trial off therapy, to reduce excess medicalization and health care costs.
conclusionA levothyroxine dose of less than 3 μg/kg at ages 1 and 2 years and less than 2.5 μg/kg at age 3 years can be predictive of T-CH. A novel risk score was developed that can be clinically applied to predict the likelihood of a successful trial off therapy for a given patient at age 1 year.
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