Evidence map›Paper›PMID 34725857›Full record

ArticleBiometrical journal. Biometrische Zeitschrift2022

Gene-environment interaction identification via penalized robust divergence.

Mingyang Ren, Sanguo Zhang, Shuangge Ma, Qingzhao Zhang

Abstract read
In one paragraph

Article in Biometrical journal. Biometrische Zeitschrift, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. High-Dimensional Gene-Environment Interaction Analysis.Annual review of statistics and its application · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mingyang RenSchool of Mathematics Sciences, University of Chinese Academy of Sciences, Beijing, P. R. China.
Sanguo ZhangSchool of Mathematics Sciences, University of Chinese Academy of Sciences, Beijing, P. R. China.ORCID 0000-0002-0688-0016
Shuangge MaDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
Qingzhao ZhangDepartment of Statistics and Data Science, School of Economics, Wang Yanan Institute for Studies in Economics, Fujian Key Lab of Statistics, Xiamen University, Fujian, P. R. China.

Funding

Novel methods for identifying genetic interactions in cancer prognosisR01CA204120 · NCI · YALE UNIVERSITY · PI Shuangge Ma · 2016 to 2026
$3.5M
NCI NIH HHS R01 CA204120NIH HHS CA204120
6 · The paper itself

Abstract

In high-throughput cancer studies, gene-environment interactions associated with outcomes have important implications. Some commonly adopted identification methods do not respect the "main effect, interaction" hierarchical structure. In addition, they can be challenged by data contamination and/or long-tailed distributions, which are not uncommon. In this article, robust methods based on

Indexed as

Diabetes Mellitus, Type 2NeoplasmsAlgorithmsComputer SimulationGene-Environment InteractionHumansdivergencegene-environment interactionhierarchical structurepenalized identificationrobustness

Identifiers

PMID34725857
PMCPMC9386692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.