ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2022
Significance of Preoperative Prognostic Nutritional Index in the Perioperative Management of Gastric Cancer.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Pooled it
- Dynamic machine learning model integrating resting energy expenditure for predicting postoperative complications after gastrectomy for gastric cancer.Journal of cancer research and clinical oncology · 2026Article
- Time-Dependent Recovery of Gastric Emptying After Gastrectomy: A 12-Month Longitudinal Study Using aAnnals of gastroenterological surgery · 2026Article
- Development and validation of a novel preoperative computed tomography staging model integrating Immune, Inflammatory, and nutritional biomarkers for prognostic prediction in gastric adenocarcinoma patients undergoing radical resection: a multicenter study.World journal of surgical oncology · 2026Article
- Postoperative Prognostic Nutritional Index as a Useful Prognostic Factor in Patients With Gastric Cancer.Annals of gastroenterological surgery · 2025Article
- The prealbumin-CD19BMC cancer · 2025Article
- Prognostic significance of the preoperative C-reactive protein-albumin-lymphocyte (CALLY) index on outcomes after gastrectomy for gastric cancer.Surgery today · 2024Article
- Preoperative prognostic nutritional index predicts long-term outcomes of patients with ampullary adenocarcinoma after curative pancreatoduodenectomy.World journal of gastrointestinal surgery · 2024Article
- Nomogram for predicting overall survival after curative gastrectomy using inflammatory, nutritional and pathological factors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Article
- Preoperative Prognostic Nutritional Index Predict Survival in Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction: A Retrospective Study Based on Propensity Score Matching Analyses.Cancer management and research · 2023Article
- Risk-stratification potential of inflammatory and nutritional biomarkers in gastric cancer: Insights from a propensity score-matched analysis.Cancer biomarkers : section A of Disease markersArticle
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Authors and funding
9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMalnutrition leads to accelerated tumor progression through the suppression of tumor immunity. The present study examined the significance of the preoperative prognostic nutritional index (PNI) for predicting postoperative survival outcomes in gastric cancer (GC).
methodsA total of 447 patients who underwent curative gastrectomy for GC were included in the present study. PNI was calculated as 10 × serum albumin (g/dl) + 0.005 × total lymphocyte counts (per mm
resultsThe optimal cutoff value of preoperative PNI for predicting overall survival (OS) was 48 based on a receiver operating characteristic curve. The 5-year OS rate was 59.5% in the PNI<48 group and 91.3% in the PNI≥48 group (p<0.001). In the first multivariate survival analysis where all explanatory variables were composed of preoperative factors alone, a PNI<48 (hazard ratio [HR] 3.33; 95% confidence interval [CI] 2.01-5.56, p<0.001), upper-third GC and cT2-T4 were identified as independent indicators of a poor OS. In the second survival analysis where explanatory variables were composed of preoperative, intraoperative, and pathological factors, a PNI<48 (HR 2.80; 95% CI 1.65-4.78, p<0.001), hypertension, open gastrectomy, intraoperative blood loss≥100g, pT2-T4, and pN+ were independent prognostic factors.
conclusionPreoperative PNI may be a useful predictor of postoperative survival outcomes both before and immediately after surgery in GC. Appropriate perioperative interventions and the meticulous surveillance of GC relapse are necessary for patients with PNI<48.
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