Evidence map›Paper›PMID 34725764›Full record

Trial reportAnnals of surgical oncology2022

Multimodal Prehabilitation During Neoadjuvant Therapy Prior to Esophagogastric Cancer Resection: Effect on Cardiopulmonary Exercise Test Performance, Muscle Mass and Quality of Life-A Pilot Randomized Clinical Trial.

Sophie K Allen, Vanessa Brown, Daniel White, David King, Julie Hunt, Joe Wainwright, Annabelle Emery, Emily Hodge, Aga Kehinde, Pradeep Prabhu and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05636969 (Effects of Multimodal Prehabilitation on Cardiorespiratory Fitness and Pulmonary Function During Neoadjuvant Therapy in Patients with Locally Advanced Lung Cancer), which is not on this map. Cited by 84 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 26 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05636969 narecruitingnot on this mapstarted 2023, after this paper: background citation

Effects of Multimodal Prehabilitation on Cardiorespiratory Fitness and Pulmonary Function During Neoadjuvant Therapy in Patients with Locally Advanced Lung Cancer

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2023 to 2027Enrolled60ConditionsNon Small Cell Lung CancerArmsMultimodal prehabilitation
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 26 syntheses or guidelines pooled it, 131 citations in OpenAlex.

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  4. Home-based multimodal prehabilitation before colorectal cancer surgery: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  17. Prehabilitation for patients undergoing neoadjuvant therapy prior to cancer resection: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Sophie K AllenDepartment of General Surgery, The Royal Surrey NHS Foundation Trust Hospital, Guildford, UK.
Vanessa BrownDepartment of General Surgery, The Royal Surrey NHS Foundation Trust Hospital, Guildford, UK.
Daniel WhiteDepartment of General Surgery, The Royal Surrey NHS Foundation Trust Hospital, Guildford, UK.
David KingFaculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
Julie HuntFaculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
Joe WainwrightFaculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
Annabelle EmeryFaculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
Emily HodgeThe Fountain Centre, St Luke's Cancer Centre, Guildford, UK.
Aga KehindeThe Fountain Centre, St Luke's Cancer Centre, Guildford, UK.
Pradeep PrabhuDepartment of Anaesthetics, The Royal Surrey NHS Foundation Trust Hospital, Guildford, UK.
Timothy A RockallDepartment of General Surgery, The Royal Surrey NHS Foundation Trust Hospital, Guildford, UK.
Shaun R PrestonDepartment of General Surgery, The Royal Surrey NHS Foundation Trust Hospital, Guildford, UK.
Javed SultanDepartment of General Surgery, The Royal Surrey NHS Foundation Trust Hospital, Guildford, UK. javed.sultan@srft.nhs.uk.
Royal Surrey NHS Foundation Trust · GBUniversity of Surrey · GB

Funding

Macmillan Cancer Support 5227431Macmillan Cancer Support 5635161
6 · The paper itself

Abstract

backgroundNeoadjuvant therapy reduces fitness, muscle mass, and quality of life (QOL). For patients undergoing chemotherapy and surgery for esophagogastric cancer, maintenance of fitness is paramount. This study investigated the effect of exercise and psychological prehabilitation on anaerobic threshold (AT) at cardiopulmonary exercise testing (CPET). Secondary endpoints included peak oxygen uptake (peak VO

methodsThis parallel-arm randomized controlled trial assigned patients with locally advanced esophagogastric cancer to receive prehabilitation or usual care. The 15-week program comprised twice-weekly supervised exercises, thrice-weekly home exercises, and psychological coaching. CPET was performed at baseline, 2 weeks after neoadjuvant therapy, and 1 week preoperatively. Skeletal muscle cross-sectional area at L3 was analyzed on staging and restaging computed tomography. QOL questionnaires were completed at baseline, mid-neoadjuvant therapy, at restaging laparoscopy, and postoperatively at 2 weeks, 6 weeks and 6 months.

resultsFifty-four participants were randomized (prehabilitation group, n = 26; control group, n = 28). No difference in AT between groups was observed post-neoadjuvant therapy. Prehabilitation resulted in an attenuated peak VO

conclusionsThis study has demonstrated some retention of cardiopulmonary fitness (peak VO

Indexed as

Esophageal NeoplasmsStomach NeoplasmsExercise TestExercise TherapyHumansMusclesNeoadjuvant TherapyPilot ProjectsPreoperative CarePreoperative ExerciseQuality of Life

Identifiers

PMID34725764
OpenAlexW3209643319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.