ArticleActa neurochirurgica2022
Trends in mortality after intensive care of patients with traumatic brain injury in Finland from 2003 to 2019: a Finnish Intensive Care Consortium study.
Article in Acta neurochirurgica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06776107 (Factors Associated With Mortality in Brain Injury at the Intensive Care Unit. A Cross-sectional Trial, 2019-2023), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Factors Associated With Mortality in Brain Injury at the Intensive Care Unit. A Cross-sectional Trial, 2019-2023 (TraVi II)
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Impact of fever on the outcome non-anoxic acute brain injury patients: a systematic review and meta-analysis.Critical care (London, England) · 2024Pooled it
- Temporal Heterogeneity of Factors Associated with Intra-ICU Mortality: A Formal Interaction Analysis of the Multi-Centre Silesian ICU Registry (2010-2020).Journal of clinical medicine · 2026Article
- Management and outcome of patients with traumatic brain injury treated in three major Nordic intensive care units: a comparative cohort study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Observational
- Outcome in adult patients with severe TBI, using a management protocol allowing a cerebral perfusion pressure ≤ 60 mmHg - a retrospective study over 10 years.Acta neurochirurgica · 2025Article
- A study of traumatic brain injury in Puerto Rico.The journal of the International Society of Physical and Rehabilitation Medicine · 2025Article
- Regional variation in traumatic brain injury patterns, management and mortality: a nationwide Swedish cohort study.Acta neurochirurgica · 2025Observational
- Developing practical machine learning survival models to identify high-risk patients for in-hospital mortality following traumatic brain injury.Scientific reports · 2025Article
- Correlations Between County-Level Social Determinants of Health and Traumatic Brain Injury-Related Mortality in the United States.Neurotrauma reports · 2025Article
- Prehospital Predictors for Urgent Neurosurgical Intervention in the Head Trauma Patient: A 2-Year Multicenter Retrospective Study.Emergency medicine international · 2023Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have suggested no change in the outcome of patients with traumatic brain injury (TBI) treated in intensive care units (ICUs). This is mainly due to the shift in TBI epidemiology toward older and sicker patients. In Finland, the share of the population aged 65 years and over has increased the most in Europe during the last decade. We aimed to assess changes in 12-month and hospital mortality of patients with TBI treated in the ICU in Finland.
methodsWe used a national benchmarking ICU database (Finnish Intensive Care Consortium) to study adult patients who had been treated for TBI in four tertiary ICUs in Finland during 2003-2019. We divided admission years into quartiles and used multivariable logistic regression analysis, adjusted for case-mix, to assess the association between admission year and mortality.
resultsA total of 4535 patients were included. Between 2003-2007 and 2016-2019, the patient median age increased from 54 to 62 years, the share of patients having significant comorbidity increased from 8 to 11%, and patients being dependent on help in activities of daily living increased from 7 to 15%. Unadjusted hospital and 12-month mortality decreased from 18 and 31% to 10% and 23%, respectively. After adjusting for case-mix, a reduction in odds of 12-month and hospital mortality was seen in patients with severe TBI, intracranial pressure monitored patients, and mechanically ventilated patients. Despite a reduction in hospital mortality, 12-month mortality remained unchanged in patients aged ≥ 70 years.
conclusionA change in the demographics of ICU-treated patients with TBI care is evident. The outcome of younger patients with severe TBI appears to improve, whereas long-term mortality of elderly patients with less severe TBI has not improved. This has ramifications for further efforts to improve TBI care, especially among the elderly.
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