ArticleThe journal of nutrition, health & aging2021
Disentangling the Relationship between Frailty and Intrinsic Capacity in Healthy Community-Dwelling Older Adults: A Cluster Analysis.
Article in The journal of nutrition, health & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implementing the National Frailty Policy in Singapore's Primary Care: A Pilot Feasibility Study of The Intrinsic Capacity ProMotion in PrimAry Care for The Frail Program (IMPACTFrail)
Holistic Integration for Healthy Longevity and Aging in Place - Establishing Full-spectrum Community-based Care System for Older People to Maintain Wellbeing Pursuing Abilities
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Detection rate of decreased intrinsic capacity of older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Intrinsic capacity and the physical frailty phenotype as complementary predictors of mortality in older Indian adults.Research square · 2026Article
- Relationship between intrinsic capacity, physical resilience and frailty among older adults patients during stroke recovery: a cross-lagged panel study.BMC geriatrics · 2026Article
- Frailty and intrinsic capacity: integrating complementary concepts to promote healthy ageing and transformation of care.Age and ageing · 2026Review
- Adapting the WHO ICOPE framework to design an integrated frailty and intrinsic capacity management community-based programme in Singapore: a programme description using the updated and modified TIDieR checklist.BMC health services research · 2026Article
- Article
- Reciprocal relationship between intrinsic capacity and social activity influenced by gender in advanced middle-aged adults in South Korea.BMC public health · 2026Article
- Development and Feasibility Assessment of an Intrinsic Capacity Program in Primary Care: Protocol for an Implementation Science Approach.JMIR research protocols · 2026Article
- Identifying health risk profiles among older adults in Kerala using machine learning: multidimensional clustering, predictive determinants, and public health implications.Frontiers in public health · 2026Article
- Prognostic value of Short Physical Performance Battery in older patients with Stage B heart failure: a prospective cohort study.BMC geriatrics · 2025Article
- Factors associated with intrinsic capacity impairment among older adults in china: a national cross-sectional survey.BMC geriatrics · 2025Article
- Metabolomic characterization of frailty identifies subtype-specific management strategies.NPJ digital medicine · 2025Article
- Reliability and Validity of a Self-administered Online Assessment of Intrinsic Capacity: A Singapore Cohort Study.Annals of geriatric medicine and research · 2025Article
- Screening for intrinsic capacity and frailty in older adults with multimorbidity in the primary care setting: application of the ICOPE tool and two frailty instruments.BMC geriatrics · 2025Article
- The vitality domain of intrinsic capacity: A scoping review of conceptual frameworks and measurements.The Journal of frailty & aging · 2025Article
- Impact of impaired intrinsic capacity on postoperative frailty in elderly patients undergoing colorectal surgery: study protocol for a single-center, prospective, cohort study.Frontiers in aging neuroscience · 2025Article
- Impact of a four-domain intrinsic capacity measure on falls: findings from the EPOSA study.Frontiers in aging · 2025Article
- Classification of Elderly Patients with Comorbidities and Their Subtypes: A Data-Driven Cluster Analysis.Clinical interventions in aging · 2025Article
- Comparison of robustness, resilience and intrinsic capacity including prediction of long-term adverse health outcomes: The KORA-Age study.The journal of nutrition, health & aging · 2025Article
- A latent profile analysis of rest-activity behavior patterns among community-dwelling older adults and its relationship with intrinsic capacity.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty and intrinsic capacity (IC) are distinct but interrelated constructs. Uncertainty remains regarding how they are related and interact to influence health outcomes. We aim to understand the relationship between frailty and IC by identifying subgroups based on frailty criteria and IC domains and studying one-year outcomes.
methodsWe studied 200 independent community-dwelling older adults (mean age 67.9±7.9 years, Modified Barthel Index (MBI) score 99±2.6). Frailty was defined by modified Fried criteria. Scores (range: 0-2) were assigned to individual IC domains (cognition, psychological, locomotion, and vitality) to yield a total IC score of 8. To identify subgroups, two-step cluster analysis was performed with age, frailty and IC domains. Cluster associations with one-year outcomes (frailty, muscle strength (grip strength, repeated chair stand test), physical performance (gait speed, Short Physical Performance Battery), function (MBI) and quality-of-life (EuroQol (EQ)-5D)) were examined using multiple linear regression adjusted for age, gender and education.
resultsThree distinct clusters were identified - Cluster 1: High IC/Robust (N=74, 37%); Cluster 2: Intermediate IC/Prefrail (N=73, 36.5%); and Cluster 3: Low IC/Prefrail-Frail (53, 26.5%). Comparing between clusters, IC domains, cognition, depressive symptoms, nutrition, strength and physical performance were least impaired in Cluster 1, intermediate in Cluster 2 and most impaired in Cluster 3. At one year, the proportion transitioning to frailty or remaining frail was highest in Cluster 3 compared to Cluster 2 and Cluster 1 (39% vs 6.9% vs 2.8%, P<0.001). Compared to Cluster 1, Cluster 3 experienced greatest declines in grip strength (β=-4.1, P<.001), MBI (β=-1.24, P=0.045) and EQ-5D utility scores (β=-0.053, P=0.005), with Cluster 2 intermediate between Cluster 1 and Cluster 3.
conclusionsAmongst independent community-dwelling older adults, IC is complementary to frailty measures through better risk-profiling of one-year outcomes amongst prefrail individuals into intermediate and high-risk groups. The intermediate group merits follow-up to ascertain longer-term prognosis.
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