ArticleThe journal of nutrition, health & aging2021
Association of C-Reactive Protein and Motoric Cognitive Risk Syndrome in Community-Dwelling Older Adults: The China Health and Retirement Longitudinal Study.
Article in The journal of nutrition, health & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Association between depressive symptom trajectories and motoric cognitive risk syndrome in older adults: a cohort study.BMC geriatrics · 2026Article
- Association of physical activity with motoric cognitive risk syndrome among the middle-aged and older adults in China.Scientific reports · 2026Article
- Observational
- Association of a novel nutritional index, the triglyceride-cholesterol-body weight index (TCBI), with incident mild cognitive impairment: CHARLS 2011-2018.Frontiers in nutrition · 2026Article
- Atherogenic index of plasma and cognitive impairment risk among hypertensive adults: evidence from a nationwide cohort study.Aging clinical and experimental research · 2025Article
- Joint associations of handgrip strength and functional disability with cognitive impairment in older adults.European journal of medical research · 2025Article
- From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome.Aging and disease · 2025Review
- Association between basal metabolic rate and cognitive function in Chinese older adults: the mediating effect of sarcopenia.BMC geriatrics · 2025Article
- Motoric Cognitive Risk Syndrome Associated With Risk of Frailty and Likelihood of Reversion in Older Adults.Journal of cachexia, sarcopenia and muscle · 2025Article
- A nomogram-based prediction model for motoric cognitive risk syndrome in patients with coronary artery disease: a cross-sectional study.Aging clinical and experimental research · 2025Article
- Association of Motoric Cognitive Risk Syndrome and High C-Reactive Protein Serum Levels With Incident Major Neurocognitive Disorder: Results From the Quebec NuAge Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Observational
- Association between atherogenic index of plasma and cognitive impairment in middle-aged and older adults: results from CHARLS.Frontiers in aging neuroscience · 2025Article
- Handgrip strength and risk of cognitive impairment across different glucose metabolism statuses: insights from the CHARLS study.Frontiers in aging neuroscience · 2025Article
- Association of a modified body shape index with cognitive impairment in middle-aged and elderly Chinese adults: a cross-sectional analysis from CHARLS.Frontiers in nutrition · 2025Article
- Air pollution is linked to cognitive decline independent of hypersensitive C-reactive protein: insights from middle-aged and older Chinese.Environmental health : a global access science source · 2024Article
- Social frailty and the incidence of motoric cognitive risk syndrome in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Biological and Physical Performance Markers for Early Detection of Cognitive Impairment in Older Adults.Journal of clinical medicine · 2024Review
- Association of peak expiratory flow with motoric cognitive risk syndrome among older adults.Frontiers in aging neuroscience · 2024Article
- Relationship between triglyceride-glucose index and cognitive function among community-dwelling older adults: a population-based cohort study.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMotoric cognitive risk syndrome (MCR) is a newly described pre-dementia syndrome characterized by cognitive complaints and slow gait and is associated with numerous adverse outcomes. Previous studies have indicated an association between C-reactive protein (CRP) and cognitive decline, but no clear relationship between CRP and MCR has been reported. The purpose of the study is to examine the associations between CRP with MCR and MCR subtypes.
methodsParticipants were 5,642 adults aged ≥60 years from the China Health and Retirement Longitudinal Study (CHARLS). MCR was defined as cognitive complaints and slow gait speed without dementia or impaired mobility. Two subtypes of MCR were defined by whether memory impairment (MI) was also present, such as MCR-MI and MCR-non-MI. MI was evaluated through the immediate recall and delayed recall in a word recall test during the CHARLS and was defined as 1.0 standard deviation or more below the mean values of the test scores in this cohort.
resultsOf the participants, 421 (7.46%) met the criteria for MCR. After multivariate adjustment, participants with higher CRP levels had an increased likelihood of MCR (fourth quartile: adjusted odds ratio [OR]=1.44; 95% confidence interval [CI]: 1.06-1.95) compared with those in the first quartile group. The OR for MCR-MI was 2.04 (95% CI: 1.35-3.09) for the highest quartile of CRP compared to the lowest quartile. No significant associations between CRP levels and odds of MCR-non-MI were observed.
conclusionsHigher CRP levels were associated with increased odds of prevalent MCR-MI but not MCR-non-MI among community-dwelling older adults.
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