Evidence map›Paper›PMID 34725639›Full record

ArticleBioMed research international2021

Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain Induced by Tooth Movement.

Yonglong Zhou, Zhiping Song, Shibiao Chen, Fen Yao, Jian Liu, Zhiqiang Ouyang, Zhengyu Liao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Differences in orthodontic pain-related behavior between adolescent and adult rats.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yonglong Zhou *Department of Orthodontics, School of Stomatology, The Key Laboratory of Oral Biomedicine, Affliated Stomatological Hospital of Nanchang University, No. 49 Fuzhou Road, Nanchang, 330006 Jiangxi Province, China.ORCID https://orcid.org/0000-0001-6051-8686
Zhiping Song *Department of Anesthesia, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006 Jiangxi Province, China.ORCID https://orcid.org/0000-0003-3136-3843
Shibiao ChenDepartment of Anesthesia, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006 Jiangxi Province, China.ORCID https://orcid.org/0000-0002-0740-4919
Fen YaoDepartment of Orthodontics, School of Stomatology, The Key Laboratory of Oral Biomedicine, Affliated Stomatological Hospital of Nanchang University, No. 49 Fuzhou Road, Nanchang, 330006 Jiangxi Province, China.ORCID https://orcid.org/0000-0001-7427-9006
Jian LiuDepartment of Orthodontics, School of Stomatology, The Key Laboratory of Oral Biomedicine, Affliated Stomatological Hospital of Nanchang University, No. 49 Fuzhou Road, Nanchang, 330006 Jiangxi Province, China.ORCID https://orcid.org/0000-0003-0218-0503
Zhiqiang OuyangDepartment of Orthodontics, School of Stomatology, The Key Laboratory of Oral Biomedicine, Affliated Stomatological Hospital of Nanchang University, No. 49 Fuzhou Road, Nanchang, 330006 Jiangxi Province, China.ORCID https://orcid.org/0000-0001-6431-1025
Zhengyu LiaoDepartment of Orthodontics, School of Stomatology, The Key Laboratory of Oral Biomedicine, Affliated Stomatological Hospital of Nanchang University, No. 49 Fuzhou Road, Nanchang, 330006 Jiangxi Province, China.ORCID https://orcid.org/0000-0001-8684-7373
Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the mechanism of catechol-O-methyltransferase (COMT) in tooth movement pain.

methodsThe experimental groups were randomly allocated into the healthy control, sham operation, model, model+shCOMT experimental, model+shCOMT control, and model+COMT antagonist groups. A tooth movement pain model was established. The pain stimulation and behavior test were performed. The duration of grooming behavior was determined. The appropriate experimental force and duration for application were selected. COMT shRNA vector was constructed and packaged as adenovirus. The shCOMT adenovirus was injected into the left infraorbital foramen. Seven days later, the trigeminal ganglia of all treatment groups were obtained. The COMT and IL-17 expressions were detected by western blot. The appropriate COMT antagonist concentration was selected. The pathological results of each group were detected by HE staining. The tooth movement distance was determined. The COMT gene expression was detected by FISH. The COMT and IL-17 expressions in the right trigeminal ganglion tissue of each group were detected by western blot.

resultsThe 60 g force and 14-day duration required the lowest stimulus intensity, the duration of grooming behavior was the longest, and the effect on COMT and IL-17 was the most significant. In the model group, formation of digestive cavity was seen in the trigeminal ganglion tissue, with infiltration of inflammatory cells, upregulation of the COMT and IL-17 expressions, and significant increase in the tooth movement distance. Compared with the model group, the shCOMT experimental group and the COMT antagonist group significantly improved the trigeminal ganglion tissue injury, significantly decreased the tooth movement distance, and significantly inhibited the COMT and IL-17 expressions.

conclusionThe efficiency of tooth movement can be influenced by interfering the COMT-related gene expression. This proves that the COMT system can regulate the orthodontic tooth movement pain.

Indexed as

AnimalsCatechol O-MethyltransferaseFacial PainGroomingInterleukin-17MalePain ManagementRatsRats, Sprague-DawleyTooth MobilityTrigeminal GanglionTRPV Cation ChannelsCatechol O-MethyltransferaseComt protein, ratIl17a protein, ratInterleukin-17TRPV Cation Channels

Identifiers

PMID34725639
PMCPMC8557060
OpenAlexW3208852710

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.