Evidence map›Paper›PMID 34725458›Full record

ArticleBritish journal of cancer2022

TIM3

Ke Chen, Yun Gu, Yifan Cao, Hanji Fang, Kunpeng Lv, Xin Liu, Xudong He, Jieti Wang, Chao Lin, Hao Liu and 5 more

Open access · greenAbstract read
In one paragraph

Article in British journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Multiple roles and mechanisms of MUC6 in cancer (Review).International journal of molecular medicine · 2025
    Review
  6. Review
  7. Review
  8. Therapeutic opportunities in EBV-positive gastric cancer subtypes.Therapeutic advances in medical oncology · 2025
    Review
  9. CD82-associated exhausted CD8Frontiers in immunology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Immunology and immunotherapy in gastric cancer.Clinical and experimental medicine · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Ke Chen *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yun Gu *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yifan Cao *Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Hanji FangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Kunpeng LvDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Xin LiuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Xudong HeDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Jieti WangDepartment of Gastric Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID http://orcid.org/0000-0002-7251-4225
Chao LinDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Hao LiuDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Heng ZhangDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Hongyong HeDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiejie XuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China. jjxufdu@fudan.edu.cn.ORCID http://orcid.org/0000-0001-7431-9063
He LiDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. li.he@zs-hospital.sh.cn.
Ruochen LiDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. rcli12@fudan.edu.cn.ORCID http://orcid.org/0000-0003-4013-3281
Sun Yat-sen University · CNFudan University · CNFudan University Shanghai Cancer Center · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a crucial immune checkpoint and is considered as an emerging target for cancer treatment. However, the clinical significance and immune-related role of TIM3

methodsThis study enrolled three cohorts, including 436 tumour tissue microarray specimens and 58 fresh tumour tissues of gastric cancer patients from Zhongshan Hospital, and 330 transcriptional data from The Cancer Genome Atlas. TIM3

resultsTumour-infiltrating TIM3

conclusionsThe abundance of tumour-infiltrating TIM3

Indexed as

Tumor EscapeTumor MicroenvironmentAgedCD8-Positive T-LymphocytesComputational BiologyDatabases, GeneticFemaleHepatitis A Virus Cellular Receptor 2HumansMalePrognosisStomach NeoplasmsSurvival RateHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2

Identifiers

PMID34725458
PMCPMC8727614
OpenAlexW3210952065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.