Evidence map›Paper›PMID 34725417›Full record

ArticleScientific reports2021

Impact of GAN-based lesion-focused medical image super-resolution on the robustness of radiomic features.

Erick Costa de Farias, Christian di Noia, Changhee Han, Evis Sala, Mauro Castelli, Leonardo Rundo

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erick Costa de FariasNOVA Information Management School (NOVA IMS), Universidade Nova de Lisboa, 1070-312, Lisbon, Portugal.
Christian di NoiaDepartment of Physics, University of Milano-Bicocca, 20126, Milan, Italy.
Changhee HanSaitama Prefectural University, Saitama, 343-8540, Japan.
Evis SalaDepartment of Radiology, University of Cambridge, Cambridge, CB2 0QQ, UK.
Mauro Castelli *NOVA Information Management School (NOVA IMS), Universidade Nova de Lisboa, 1070-312, Lisbon, Portugal. mcastelli@novaims.unl.pt.
Leonardo Rundo *Department of Radiology, University of Cambridge, Cambridge, CB2 0QQ, UK. lr495@cam.ac.uk.

Funding

Cancer Research UK 28667Cancer Research UK C42780/A27066Wellcome TrustWellcome Trust 215733/Z/19/Z
6 · The paper itself

Abstract

Robust machine learning models based on radiomic features might allow for accurate diagnosis, prognosis, and medical decision-making. Unfortunately, the lack of standardized radiomic feature extraction has hampered their clinical use. Since the radiomic features tend to be affected by low voxel statistics in regions of interest, increasing the sample size would improve their robustness in clinical studies. Therefore, we propose a Generative Adversarial Network (GAN)-based lesion-focused framework for Computed Tomography (CT) image Super-Resolution (SR); for the lesion (i.e., cancer) patch-focused training, we incorporate Spatial Pyramid Pooling (SPP) into GAN-Constrained by the Identical, Residual, and Cycle Learning Ensemble (GAN-CIRCLE). At [Formula: see text] SR, the proposed model achieved better perceptual quality with less blurring than the other considered state-of-the-art SR methods, while producing comparable results at [Formula: see text] SR. We also evaluated the robustness of our model's radiomic feature in terms of quantization on a different lung cancer CT dataset using Principal Component Analysis (PCA). Intriguingly, the most important radiomic features in our PCA-based analysis were the most robust features extracted on the GAN-super-resolved images. These achievements pave the way for the application of GAN-based image Super-Resolution techniques for studies of radiomics for robust biomarker discovery.

Indexed as

AlgorithmsHumansImage Processing, Computer-AssistedLungLung NeoplasmsMachine LearningTomography, X-Ray Computed

Identifiers

PMID34725417
PMCPMC8560955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.