Evidence map›Paper›PMID 34725357›Full record

ArticleNature communications2021

Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.

Arthur Neuberger, Kirill D Nadezhdin, Alexander I Sobolevsky

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. TRPV6-Mediated CaCancers · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. TRPV6 channel function is involved in endometrial epithelial cell CaCellular and molecular life sciences : CMLS · 2025
    Article
  12. Article
  13. A mechanism of CALHM1 ion channel gating.American journal of physiology. Cell physiology · 2025
    Article
  14. Review
  15. Forty sites of TRP channel regulation.Current opinion in chemical biology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Arthur Neuberger *Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-7744-6559
Kirill D Nadezhdin *Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-7140-0779
Alexander I SobolevskyDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. as4005@cumc.columbia.edu.ORCID 0000-0001-5181-8644
Columbia University · USColumbia University Irving Medical Center · US

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
Structure and Function of AMPA subtype ionotropic glutamate receptorsR01NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KURNIKOVA, MARIA G, SOBOLEVSKY, ALEXANDER · 2013 to 2022
$4.3M
Structure and function of Transient Receptor Potential ChannelsR01CA206573 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2017 to 2026
$3.8M
Single-Particle Cryo-EM Characterization of AMPA Receptor Functional StatesR01NS107253 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2018 to 2026
$3.5M
Structural and functional principles of activation and regulation of the transient receptor potential channel TRPV3.R01AR078814 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2022 to 2026
$2.8M
Structure and Function of Ionotropic Glutamate ReceptorsR37NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2024 to 2026
$1.7M
NCI NIH HHS HHSN261200800001ENCI NIH HHS R01 CA206573NIAMS NIH HHS R01 AR078814NIGMS NIH HHS U24 GM129541NIGMS NIH HHS U24 GM129547NINDS NIH HHS R01 NS083660NINDS NIH HHS R01 NS107253NINDS NIH HHS R37 NS083660
6 · The paper itself

Abstract

TRPV6 is a calcium-selective ion channel implicated in epithelial Ca

Indexed as

Antifungal AgentsBinding SitesCalciumCalcium Channel BlockersCalcium ChannelsEconazoleHumansModels, MolecularRuthenium RedTRPV Cation ChannelsAntifungal AgentsCalciumCalcium Channel BlockersCalcium ChannelsEconazoleRuthenium RedTRPV6 protein, humanTRPV Cation Channels

Identifiers

PMID34725357
PMCPMC8560856
OpenAlexW3211040799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.