Evidence map›Paper›PMID 34725354›Full record

ArticleScientific reports2021

A novel method quantifying caries following orthodontic treatment.

Christina Erbe, Luisa Hartmann, Irene Schmidtmann, Daniela Ohlendorf, Heinrich Wehrbein

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07291830 (Clinical Effectiveness of a Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07291830 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Clinical Effectiveness of a Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding: A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of BaghdadRan2026 to 2026Enrolled45ConditionsWhite Spot Lesions, Enamel DemineralizationArmsRemineralizing self-etch primer (M-SEP, SEP 1), Standard self-etch primer (P-SEP, SEP 2)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Christina ErbeDepartment of Orthodontics, University Medical Center of the Johannes Gutenberg-University, Augustusplatz 2, 55131, Mainz, Germany. erbe@uni-mainz.de.
Luisa HartmannDepartment of Orthodontics, University Medical Center of the Johannes Gutenberg-University, Augustusplatz 2, 55131, Mainz, Germany.
Irene SchmidtmannInstitute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.
Daniela OhlendorfInstitute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe-University, Frankfurt am Main, Germany.
Heinrich WehrbeinDepartment of Orthodontics, University Medical Center of the Johannes Gutenberg-University, Augustusplatz 2, 55131, Mainz, Germany.
University Medical Center of the Johannes Gutenberg University Mainz · DEGoethe University Frankfurt · DEJohannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This retrospective pilot study used a newly developed evaluation tool to assess the prevalence and incidence of White Spot Lesions (WSL) before and after multibracket appliance (MB) therapy. Digital photographs of 121 adolescent patients (63 ♂, 58 ♀) with metal brackets were analyzed retrospectively before and after MB therapy. The labial surfaces of anterior teeth, canine teeth, and premolars in the upper (UJ) and lower jaws (LJ) were evaluated using the Enamel Decalcification Index (EDI) by Banks and Richmond (Eur J Orthod, 16(1):19-25, 1994, levels 0-3) and a specially developed digitally scaled graticule with concentric circles to quantify the extent of WSL (in %). The statistical data analysis was based on crosstabulations and logistic regression. Before MB, 69.4% of the patients presented at least one WSL and 97.5% after, an increase of 28.1%. Before MB, 18.4% of the tooth surfaces (TS) showed an EDI level of 1-3. After MB, 51.8% of the TS featured WSL. 18.2% of the TS showed a WSL to the extent of ≥ 20-100% before and 52.3% after MB. The incidence in the UJ (71-79%) as well as the LJ (64-76%) was highest for the first and second premolars and lowest for LJ incisors (22-35%). The probability for developing a new distal WSL is higher than developing gingival, mesial or occlusal WSL. Labial MB therapy drastically increases the risk of developing WSL. We verified a concise quantification of the extent of labial WSL with the evaluation index.

Indexed as

Orthodontic BracketsAdolescentDental CariesDental Caries SusceptibilityFemaleHumansMalePhotography, DentalPilot ProjectsRetrospective StudiesTooth Demineralization

Identifiers

PMID34725354
PMCPMC8560919
OpenAlexW3209088479

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.